Results 21 to 30 of about 34,930 (196)

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]

, 2015
Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B., Haferkamp, S., Hufnagel, A.L., Kneitz, S., Leikam, C., Meierjohann, S., Murphy, D.J., Mühling, B., Nanda, I., Otto, C., Schartl, M., Schmid, M., Wagner, T.U.   +12 more
core   +2 more sources

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source

Association of MC1R Variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study [PDF]

, 2010
<p><b>Background</b> Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes,
Affleck, P, Aguilera, P, Al\uf3s, L, Ancero, A, Arcangeli, F, Argu\ueds, P, Avril, Mf, Avril, Mf, Azizi, E, Badenas, C, Barrett, Jh, Battistuzzi, L, Bergman, W, Bergman, W, Bertazzi, Pa, BIANCHI-SCARR\uc0, G, Bianhi-Scarr\ue0, G, Bishop, Dt, Bishop, Dt, Borg, \uc5, BRESSAC-DE PAILLERETS, B, Bressac-de Paillerets, B, Bruno, W, Bruno, W., Butille, Ja, Calista, D, Calista, D, Campo, A, Capirossi, D, Carrera, C, Carrera, C, Castel, T, Cervera, R, Chan, M, Chaudru, V, Chaudru, V, Conill, C, Corda, E, Cuellar, F, de Lichy, M, Demenais, F, Duffy, Dl, Elder, D, Elder, De, Gabriel, D, Gargiulo, S, Ghiorzo, P, Ghiorzo, P., Gillanders, E, Gliori, S, Goldstein, Am, Goldstein, Am, Gonzalez, M, Gruis, N, Gruis, Na, H\uf6iom, V, H\uf6iom, V, Hansson, J, Hansson, J, Harbst, K, Harland, M, Harland, M, Harrison, J, Haynes, S, Hayward, Nk, Hayward, Nk, Hogg, D, Hogg, D, Holland, Ea, Holland, Ea., Iglesias, P, Iles, Mm, Ingvar, C, Ingvar, C, J\uf6nsson, G, Jeannin, P, Kanetsky, P, Kanetsky, Pa, Karpavicius, B, Kefford, Rf, Kukalizch, K, Landi, G, Landi, Mt, Landi, Mt, Lang, J, Lang, Jm, Leake, S, Lesueur, F, Lind\ue9n, D, Loo, Jc, M\ue5sb\ue4ck, A, Macgregor, S, Mack, T, Mackie, R, Mackie, Rm, Malvehy, J, Mann, Gj, Mann, Gj, Marti-Laborda, R, Martin, Ng, Maubec, E, Melanoma Genetics Consortium: Demenais, F, Mila, M, Ming, M, Ming, Me, Minghetti, P, Mitra, N, Mohamdi, H, Mohamdi, H, Montgomery, Gw, Nasti, S, NEWTON BISHOP JA,, Newton Bishop JA,, Nielsen, K, Njauw, Cj, Njauw, Cn, Ogbah, Z, Olsson, H, Olsson, H, Origone, P, Palmer, J, Palou, J, Parossian, S, Pastorino, L, Pastorino, L, Puig, S, Puig, S, Queirolo, P, RANDERSON-MOOR, J, Randerson-Moor, J, Ruffin, A, Rull, R, S\ue1nchez, M, Schmid, H, Stark, M, Taylor, Jc, Taylor, Y, Tesema, L, Tsao, H, Tsao, H, Tucker, Ma, Tucker, Ma, Tuominen, R, VAN BELLE, P, Van Belle, P, VAN DER VELDEN, P, van der Velden, P, van Mourik, L, van Nieuwpport FA,, Vidal-Sicart, S, Vilalta, A, Vilella, R, Whiteman, Dc, Whittaker, L, Yang, Xr, Yang, Xr   +155 more
core   +2 more sources

Visualizing Turner Syndrome

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Turner syndrome (TS) continues to present a diagnostic challenge to healthcare professionals. The diagnostic challenges associated with TS result in delayed treatment and clinical care. Here we provide an update of the physical appearance of girls and women with TS by presenting clinical photographs and detailed clinical descriptions of 25 ...
Kirstine Stochholm, Astrid Bruun Rasmussen, Anne Skakkebæk   +2 more
wiley   +1 more source

Why Engineers Should Read More Novels

Chemie Ingenieur Technik, EarlyView.
What do engineers do? And what should they work on? A surprising answer is outlined in this essay, which argues that reading novels holds the key for addressing both questions. Novels train the imagination as well as our ethical abilities – skills that are essential for developing future‐proof technologies.
Michael Kuhn
wiley   +1 more source

Knowledge Transfer for Melanoma Screening with Deep Learning

, 2017
Knowledge transfer impacts the performance of deep learning -- the state of the art for image classification tasks, including automated melanoma screening.
Avila, Sandra, Bittencourt, Flávia Vasques, Fornaciali, Michel, Menegola, Afonso, Pires, Ramon, Valle, Eduardo   +5 more
core   +1 more source

Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest [PDF]

, 2015
Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown.
Adams, Peter D., Athineos, Dimitris, Berger, Shelley L., Blyth, Karen, Brock, Claire, Clark, William, Cole, John J., Dikovskaya, Dina, Hewitt, Rachael N., Karim, Saadia A., Leach, Joshua D. G., Marchesi, Francesco, Mason, Susan M., McGarry, Lynn, Morton, Jennifer P., Nixon, Colin, Sammons, Morgan A., Tait, Stephen W., van Tuyn, John, Wu, Hong, Zhu, Jiajun   +20 more
core   +2 more sources

Fluorescence Lifetime Imaging Microscopy Analysis of Isolated Melanosomes

ChemPhysChem, Accepted Article.
Melanosomes are organelles found in a wide variety of tissues throughout the animal kingdom. They contain a variety of biological molecules, but the dominant constituent is the pigment melanin, and many functions ascribed to melanosomes, such as photoprotection, are uniquely enabled by the chemical properties and structures of the melanins they contain.
Vladislav Yakovlev, Mykyta Kizilov, Sujeong Jung, Vsevolod Cheburkanov   +3 more
wiley   +1 more source

PSEUDORADICULAR NEVUS [PDF]

The Journal of Nervous and Mental Disease, 1921
n ...
openaire   +1 more source

Epidermal nevus

Dermatology Online Journal, 2010
A healthy 25-year-old man presented with a widespread, non-organoid, non-epidermolytic epidermal nevus. In addition to extensive hyperpigented patches and thin plaques following Blaschko lines, there were superimposed psoriasiform plaques on the elbows and warty plaques on the upper trunk. Striate palmar keraoderma also was evident.
Gonzalez, Mercedes E, Jabbari, Ali, Tlougan, Brook E, Mandal, Rajni, Schaffer, Julie V   +4 more
openaire   +4 more sources