Results 141 to 150 of about 10,524,681 (309)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
DOGA KAVRAMININ TARİHSEL GELİŞİMİ
Felsefe Dünyası, 2007 Hasan ASLAN, "DOGA KAVRAMININ TARİHSEL GELİŞİMİ" FELSEFE DÜNYASI DERGİSİ, SAYI ...
Hasan Aslan
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
La increencia que nos acecha: el espejismo de una nueva religiosidad
Estudios Eclesiásticos, 1992 Desde hace un tiempo, nos plantea el autor, se ha venido hablando de un nuevo retorno a lo sagrado, una nueva conciencia orientada a la dimensión de los valores religiosos, una nueva sensibilidad hacia el Misterio trascendente, pero, esta nueva ...
Antonio Jiménez Ortiz
doaj
Social media: A new-age educational platform for the millennial ophthalmologist! [PDF]
Indian J Ophthalmol, 2023 Joshi SM +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The effect of New Zealand Superannuation eligibility age on the labour force participation of older people [PDF]
New Zealand experienced a sharp rise in labour force participation rates among older people over the period 1991?2001. This stands in contrast to the experience of most other OECD countries where such participation rates have been in steady decline.
Roger Hurnard
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Extracellular protein homeostasis: The dawning of a new age for human disease therapies? [PDF]
Clin Transl Med, 2023 Wilson MR, Satapathy S, Vendruscolo M.
europepmc +1 more source