Results 131 to 140 of about 10,524,681 (309)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Shifting Beliefs on Digital Platforms: The Case of the ‘Godless Utopia’ of Binnur Duman Academy

Medya ve Din Araştırmaları Dergisi
Technological developments and the introduction of mass media into our lives have led to an increase in the visibility of religion on digital platforms.
Merve Bahadur, İhsan Çapcıoğlu
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Epstein-Barr virus and multiple sclerosis: the dawn of a new age. [PDF]

Clin Transl Immunology, 2023
Phan TG.
europepmc   +1 more source

New age data on the geological evolution of Southern India [PDF]

The Peninsular Gneisses of Southern India developed over a period of several hundred Ma in the middle-to-late Archaean. Gneisses in the Gorur-Hassan area of southern Karnataka are the oldest recognized constituents: Beckinsale et al.
Chadwick, B., Friend, C. R. L., Moorbath, Stephen, Ramakrishnan, M., Taylor, Paul N., Viswanatha, M. N.   +5 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Coccidioidal Pulmonary Cavitation: A New Age. [PDF]

J Fungi (Basel), 2023
Kooner L, Munoz A, Garcia A, Kaur A, Sharma R, Bustamante V, Narang V, Thompson GR, Kuran R, Berjis A, Johnson RH, Heidari A.   +11 more
europepmc   +1 more source

A New World Chaos? International Institutions in the Information Age [PDF]

The technological revolutions that underlie the new information age will tax considerably the abilities of existing international institutions to bring order to international relations.
Kerr, William A.
core   +1 more source