Results 121 to 130 of about 6,634,227 (307)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Constructing ethnographic relationships: Reflections on key issues and struggles in the field. [PDF]

open access: yes, 2005
An ethnographer shares his insights from the field about constructing relationships in research. Focusing on a case study in a New Zealand area school, he reflects on his experiences in the field and the key issues he struggled with related to building ...
Cavanagh, Tom
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Functionalised nanostructured polyaniline? A new substrate for building adaptive sensing surfaces [PDF]

open access: yes, 2008
A new method for covalently binding side-chains to the surface of solution based conducting polymer nanostructures is introduced in this paper. Modification of the structures is achieved by convenient reflux in the presence of a nucleophile, and post ...
Bell, Steven   +2 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

University College London: Library DDA works PPG15 justification. Conservation strategy report. [PDF]

open access: yes, 2004
Introduction: This report has been prepared for the Estates and Facilities Division of University College London (UCL). UCL needs to make alterations to the Wilkins building to improve access to the library (on its upper floors) by the end of the year
Filmer-Sankey, W., Markham, L.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Performance of Two 18-Story Steel Moment-Frame Buildings in Southern California During Two Large Simulated San Andreas Earthquakes [PDF]

open access: yes, 2006
Using state-of-the-art computational tools in seismology and structural engineering, validated using data from the Mw=6.7 January 1994 Northridge earthquake, we determine the damage to two 18-story steel moment-frame buildings, one existing and one new ...
Komatitsch, Dimitri   +2 more
core  

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