Results 71 to 80 of about 29,602,681 (295)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Is there Progress? An Overview of Select Biomarker Candidates for Major Depressive Disorder
Frontiers in Psychiatry, 2016 Major Depressive Disorder (MDD) contributes to a significant worldwide disease burden, expected to be second only to heart disease by 2050. However, accurate diagnosis has been a historical weakness in clinical psychiatry.
Juan Joseph Young +7 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Molecules, 2017 6-Thioguanine, an immunosuppressant and anticancer prodrug, has been shown to induce DNA damage and cell death following exposure to UVA radiation. Its metabolite, 6-thioguanosine, plays a major role in the prodrug’s overall photoreactivity.
Brennan Ashwood +2 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Cancer ReportsBackground Ataxia telangiectasia mutated (ATM) mutations represent the most common homologous recombination deficiency (HRD) mutation in non‐small cell lung cancer (NSCLC). However, their therapeutic role in NSCLC has not been established.
Zhiting Tang +5 more
doaj +1 more source
A NEW CLOTHING CASE FOR THE SOLDIER. [PDF]
Journal of the American Medical Association, 1886 The science of medicine has for its purpose not only the cure of disease, but, infinitely more important, the prevention of sickness and of suffering. Students of the medical profession—and, as long as we are faithful to our calling, we who are known as medical doctors must also be students—investigate matters pertaining to prevention and cure in every
openaire +2 more sources
A NEW OPHTHALMIC VISITING CASE. [PDF]
JAMA: The Journal of the American Medical Association, 1903 This little visiting case which I present to the profession and which is herein portrayed is of especial interest to oculists; it can, of course, be used by the physician in general work in connection with his ophthalmic cases. As will be seen by the cut, it contains all the essentials commonly used in the treatment of eye cases, each dropper being ...
openaire +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source