Results 31 to 40 of about 401,153 (265)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A large-scale LLM-generated dataset for exploring social interactions and urban experiences across 21 global cities

Discover Data
Objectives We present a dataset designed to evaluate the capacity of Large Language Models (LLMs) to generate context-aware simulations of urban experiences across diverse cultural and socioeconomic settings.
Jose Balsa-Barreiro, Shahid Rabbani, Djellel Difallah, Monica Menendez, Manuel Cebrian   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A multi-factor approach to understanding socio-economic segregation in European capital cities [PDF]

, 2015
The research leading to the results presented in this chapter has received funding from the Estonian Research Council (Institutional Research Grant IUT no.
Marcinczak, S., Musterd, Sako, van Ham, Maarten, Tammaru, T., Musterd, S., Tammaru, Tiit, Marcińczak, Szymon, Tammaru, T. (author), Musterd, S. (author), Van Ham, M. (author), Marcinczak, S. (author), Musterd, S.; id_orcid, Van Ham, M., Ham, Maarten van   +13 more
core   +1 more source

How well do climate adaptation policies align with risk-based approaches? An assessment framework for cities

, 2021
Many cities around the world are undertaking adaptation planning processes in contexts of considerable uncertainty due to climate risks. However, new evidence suggests that current adaptation policies are failing to fully incorporate risk-related ...
Galarraga, I., Olazabal, M., Sainz de Murieta Zugadi, Elisa, Sainz de Murieta, Elisa, Olazabal, Marta, Galarraga, Ibon   +5 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Growing the Australian innovation economy: an examination of innovation ecosystems in the United States [PDF]

, 2016
Introduction Innovative cities drive economic growth, deliver new jobs, and create thriving communities for residents to live, work, play, invest and visit.
Future Cities Collaborative
core  

Inter-Organisational Collaboration: A Qualitative Study of Collaboration Arrangements in the Public and Community Housing Sector in New Zealand

Urban Science
Complex problems are rarely solved on their own. One such problem facing Aotearoa New Zealand is the provision of affordable housing that enhances the wellbeing of tenants and local communities.
Mary Anne Teariki, Guy Penny, Philippa Howden-Chapman   +2 more
doaj   +1 more source

Investigation on Nonlinear Flow Behavior through Rock Rough Fractures Based on Experiments and Proposed 3-Dimensional Numerical Simulation

Geofluids, 2020
Rock fractures as the main flow channels, their morphological features, and spatial characteristics deeply influence the seepage behavior. Reservoir sandstones as a case study, four splitting groups of fractures with different roughness were scanned to ...
Xianshan Liu, Man Li, Nandou Zeng, Tao Li   +3 more
doaj   +1 more source