Results 41 to 50 of about 401,153 (265)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Permeability of the Hydrated Shale under Cyclic Loading and Unloading Conditions

Geofluids, 2020
The hydrated shales under cyclic loading and unloading conditions are common for the shale reservoir development; corresponding mechanical properties and permeability evolution are very significant and should be deeply researched.
Liu Xianshan, Li Man, Xu Ming, Kang Zhiyong   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Investigation on Dynamic Factors of Railway Steel-Plate–Concrete Composite Beam Bridges With Small and Medium Spans

Advances in Civil Engineering
Dynamic factor (DF) is an important indicator for describing the dynamic action of a train on a bridge. For small- and medium-span bridges, although existing research and codes have studied and specified the DF of steel–concrete composite beam bridges ...
Jin Di, Yi Su, Yuxuan Han, Jinming Luo, Fengjiang Qin, Rui Yan   +5 more
doaj   +1 more source

Deep-Learning-Based Bughole Detection for Concrete Surface Image

Advances in Civil Engineering, 2019
Bugholes are surface imperfections that appear as small pits and craters on concrete surface after the casting process. The traditional measurement methods are carried out by in situ manual inspection, and the detection process is time-consuming and ...
Gang Yao, Fujia Wei, Yang Yang, Yujia Sun   +3 more
doaj   +1 more source

Testing and modeling of rockfill materials: A review

Journal of Rock Mechanics and Geotechnical Engineering, 2016
The research development of rockfill materials (RFM) was investigated by a series of large-scale triaxial tests. It is observed that confining pressure and particle breakage play important roles in the mechanical property, dilatancy relation and ...
Yang Xiao, Hong Liu, Wengang Zhang, Hanlong Liu, Feng Yin, Youyu Wang   +5 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Pandemic legacies: funding urban recovery in Europe and the US

, 2023
Catarina Heeckt, from LSE Cities, argues that the European Union has missed a key opportunity to empower cities – and that there is much to learn from the bold approach taken in the ...
Heeckt, Catarina
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