Results 111 to 120 of about 2,993,444 (316)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A review of the genus Stephanorhynchus White, 1846 (Coleoptera: Curculionidae: Eugnomini), with a description of three new genera and one new species from New Zealand

open access: yesThe European Zoological Journal
Stephanorhynchus White, 1846 is a eugnomine weevil genus endemic to New Zealand, with 18 nominal taxa described within the genus. Examination of the type specimens of these taxa with greater understanding of related genera has led to the distinction of ...
M. A. Mazur, S. D. J. Brown
doaj   +1 more source

New developments in acne treatment: role of combination adapalene–benzoylperoxide

open access: yes, 2016
Su Youn Kim, Falk R Ochsendorf Clinic for Dermatology, Venereology, and Allergology, University Hospital, Frankfurt/M, Germany Abstract: The fixed-dose combination adapalene 0.1%/benzoylperoxide 2.5% (A/BPO) was introduced as an acne vulgaris ...
Kim SY, Ochsendorf FR
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Discovery of New AKT1 Inhibitors by Combination of In silico Structure Based Virtual Screening Approaches and Biological Evaluations

open access: yes, 2019
AKT1 is emerging as a useful target for treating cancer. Herein, we discovered a new set of ligands that inhibit the AKT1, as shown by in vitro binding and cell line studies, using a newly designed virtual screening protocol that combines structure-based
Denisse A., Gutierrez   +3 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A New Species and New Combinations in Calibrachoa (Solanaceae)

open access: yesNovon, 1997
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
João Renato Stehmann   +3 more
openaire   +3 more sources

A PERTURBATION­BASED APPROACH FOR MULTI­CLASSIFIER SYSTEM DESIGN [PDF]

open access: yes, 2004
Microsoft, Motorola, Siemens, Hitachi, IAPR, NICI, IUF This paper presents a perturbation­based approach useful to select the best combination method for a multi­classifier system.
Dimauro, G.   +5 more
core  

Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy. [PDF]

open access: yes, 2011
INTRODUCTION: The first-line therapy for the intermittent preventive treatment of malaria in pregnancy (IPTp) is sulphadoxine-pyrimethamine (SP).
Chandramohan, Daniel   +3 more
core   +1 more source

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