Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Notification that new names of prokaryotes, new combinations and new taxonomic opinions have appeared in volume 75, part 4 of the IJSEM. [PDF]
Int J Syst Evol MicrobiolOren A, Göker M.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Proposal of <i>Allobrachymonas</i> gen. nov. and three new combinations as replacement names for the illegitimate prokaryotic genus name <i>Brachymonas</i>, proposal of <i>Allobosea</i> gen. nov. and 12 new combinations as replacement names for the illegitimate prokaryotic genus name <i>Bosea</i> and proposal of <i>Alloboseaceae</i> fam. nov. as a replacement name for the illegitimate family name <i>Boseaceae</i>. [PDF]
Int J Syst Evol MicrobiolDeshmukh UB, Oren A.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Notification that new names of prokaryotes, new combinations and new taxonomic opinions have appeared in volume 75, part 3 of the IJSEM. [PDF]
Int J Syst Evol MicrobiolOren A, Göker M.
europepmc +1 more source
The in vitro effect of new combinations of carbapenem-β-lactamase inhibitors for Mycobacterium abscessus. [PDF]
Antimicrob Agents Chemother, 2023 Fröberg G +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Notification that new names of prokaryotes, new combinations and new taxonomic opinions have appeared in volume 75, part 5 of the <i>IJSEM</i>. [PDF]
Int J Syst Evol MicrobiolOren A, Göker M.
europepmc +1 more source