Results 171 to 180 of about 20,149,345 (212)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Notification that new names of prokaryotes, new combinations, and new taxonomic opinions have appeared in volume 74, part 7 of the IJSEM. [PDF]

Int J Syst Evol Microbiol
Oren A, Göker M.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Rpv10.2: A Haplotype Variant of Locus Rpv10 Enables New Combinations for Pyramiding Downy Mildew Resistance Traits in Grapevine. [PDF]

Plants (Basel)
Höschele T, Malagol N, Bori SO, Müllner S, Töpfer R, Sturm J, Zyprian E, Trapp O.   +7 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Notification that new names of prokaryotes, new combinations, and new taxonomic opinions have appeared in volume 74, part 6 of the IJSEM. [PDF]

Int J Syst Evol Microbiol
Oren A, Göker M.
europepmc   +1 more source

Validation List no. 217. Valid publication of new names and new combinations effectively published outside the IJSEM. [PDF]

Int J Syst Evol Microbiol
Oren A, Göker M.
europepmc   +1 more source

The yeast genus Tardiomyces gen. nov. with one new species and two new combinations. [PDF]

Infection
Spruijtenburg B, de Souza Lima BJF, Tosar STG, Borman AM, Andersen CT, Nizamuddin S, Ahmad S, de Almeida Junior JN, Vicente VA, Nosanchuk JD, Buil JB, de Hoog S, Meijer EFJ, Meis JF, de Groot T.   +14 more
europepmc   +1 more source

Proposal of <i>Allogeochorda</i> gen. nov., <i>Allogeochorda subterranea</i> comb. nov., <i>Allostigmatella</i> gen. nov. and four new combinations and <i>Allosphingorhabdus</i> gen. nov. and <i>Allosphingorhabdus lutea</i> comb. nov. as replacement names for the illegitimate genus names <i>Geochorda</i>, <i>Stigmatella</i> and <i>Alterisphingorhabdus</i> and their species. [PDF]

Int J Syst Evol Microbiol
Kostovski M, Oren A.
europepmc   +1 more source

Notification that new names of prokaryotes, new combinations, and new taxonomic opinions have appeared in volume 74, part 5 of the IJSEM. [PDF]

Int J Syst Evol Microbiol
Oren A, Göker M.
europepmc   +1 more source