Results 51 to 60 of about 170,375 (252)

Development of BsPhyC phytase-enriched tomatoes to enhance micronutrient bioavailability in plant-based diets

Current Plant Biology
Phytic acid (myo-inositol hexakisphosphate), a predominant antinutrient in plant-based diets, limits the bioavailability of essential minerals in monogastric animals and humans.
Tanushri Kaul, Chinreddy Subramanyam Reddy, Rashmi Kaul, Arulprakash Thangaraj, Jyotsna Bharti, Rachana Verma, Puja Chakraborty, Isha Gupta, R. Shubhra Maithreyi, Sugyanpreet   +9 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Obtaining new Ruscus products using Gamma radiation

Ornamental Horticulture, 2020
Ruscus is an evergreen shrub that offers dark-green glossy foliage used as green additions to bouquets and flower arrangements. One of the most significant ways to obtain new varieties of crop and ornamental plants is to induce mutations by radiation ...
Yaarit Kutsher, Nir Hazenshprung, Orit Amir-Segev, Lianne Merchuk-Ovnat, Dalia Evenor, Moshe Reuveni   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Jujube as a Florida Fruit Crop

EDIS
Despite being cultivated in China for millennia, the Chinese jujube is mostly unknown to Western consumers. The fruits are borne from vigorous trees that are tolerant to drought and other stresses, as well as disease.
Kevin M. Folta, Dustin Huff, Ali Sarkhosh   +2 more
doaj   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effects of climate change on food security and nutrition in India: A systematic review

Current Research in Environmental Sustainability
Climate change poses a complex challenge to food and nutritional security, impacting human health, well-being, and sustainable development. India, facing heightened vulnerability in agriculture and a growing population surpassing 1.3 billion, requires a ...
Abhishek Das, Shalander Kumar, Kavitha Kasala, S. Nedumaran, Pradnya Paithankar, Abhay Kumar, Ayushi Jain, Vijay Avinandan   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Genetic Diversity and Population Structure of Jujube Cultivars in the United States Revealed by Single Nucleotide Polymorphism Markers

Journal of the American Society for Horticultural Science
The nutritional and medicinal significance of jujube (Ziziphus jujuba) has led to persistent efforts in genomics to accelerate the utilization of its germplasm resources.
Dikshya Sapkota, Dapeng Zhang, Sunchung Park, Lyndel W. Meinhardt, Dennis N. Lozada, Robert Steiner, Shengrui Yao   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source