Results 61 to 70 of about 69,557 (255)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
A realistic theory of E6 unification through novel intermediate symmetries
Journal of High Energy PhysicsWe propose a non-supersymmetric E6 GUT with the scalar sector consisting of 650 ⨁ 351′ ⨁ 27. Making use of the first representation for the initial symmetry breaking to an intermediate stage, and the latter two representations for second-stage breaking ...
K. S. Babu, Borut Bajc, Vasja Susič
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Multi-lepton jets from quadruple Z′ via the Higgs decay at LHC
Journal of High Energy PhysicsWe investigate multi-lepton jet events from the decay of the 125 GeV Higgs boson (h) into quadruple new gauge bosons (Z′) at the LHC. Such an exotic decay is realized via the process of h → ϕϕ → Z′Z′Z′Z′ with new scalar boson ϕ in models with an ...
Jinmian Li, Takaaki Nomura, Kei Yagyu
doaj +1 more source
New N=2 supersymmetric gauge theories: The double tensor multiplet and its interactions
, 2000 The double tensor multiplet of D=4, N=2 supersymmetry, relevant to type IIB superstring vacua, is derived and its gauge invariant and N=2 supersymmetric interactions are analysed, both self-interactions and interactions with vector multiplets and hypermultiplets.
openaire +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Dark gauge-mediated supersymmetry breaking with a massless dark photon
Journal of High Energy PhysicsWe study dark gauge-mediated supersymmetry breaking (dark GMSB) in a theory with a new unbroken U(1) D local symmetry and massless dark photon. Messenger fields charged under both Standard Model and dark gauge symmetries produce new soft supersymmetry ...
Brian Batell +3 more
doaj +1 more source