Results 51 to 60 of about 20,747,688 (258)
A First Class Constraint Generates Not a Gauge Transformation, But a Bad Physical Change: The Case of Electromagnetism [PDF]
, 2013 In Dirac-Bergmann constrained dynamics, a first-class constraint typically does not _alone_ generate a gauge transformation. By direct calculation it is found that each first-class constraint in Maxwell's theory generates a change in the electric field ...
Pitts, J. Brian, J. Brian Pitts
core +2 more sources
Hide and seek: how PDFs can conceal new physics
Journal of High Energy Physics, 2023 The interpretation of LHC data, and the assessment of possible hints of new physics, require the precise knowledge of the proton structure in terms of parton distribution functions (PDFs). We present a systematic methodology designed to determine whether
Elie Hammou +7 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Quark-universal U(1) breaking scalar at the LHC
Journal of High Energy PhysicsIf the quarks or leptons are charged under a new U(1) gauge symmetry, then besides a Z′ boson there must exist at least one new boson whose decay products include Standard Model particles. In the case of a minimal symmetry breaking sector, that new boson
Lorin Armbruster +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Searching for a new light gauge boson with axial couplings in muon beam dump experiments
Journal of High Energy PhysicsWe present a formalism for new U(1) interactions involving weak hypercharge, baryon, and lepton numbers, and a possible axial symmetry generator F A in the presence of a second Brout-Englert-Higgs doublet.
Pierre Fayet, María Olalla Olea-Romacho
doaj +1 more source
Journal of High Energy Physics, 2023 Hidden sectors are ubiquitous in supergravity theories, in strings and in branes. Well motivated models such as the Stueckelberg hidden sector model could provide a candidate for dark matter.
Amin Aboubrahim +4 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Are gauge symmetry transformations observable? [PDF]
, 2003 In a recent paper in the British Journal for the Philosophy of Science, Kosso discussed the observational status of continuous symmetries of physics. While we are in broad agreement with his approach, we disagree with his analysis.
Brading, Katherine +3 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source