Results 41 to 50 of about 227,046 (302)

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

One size does not fit all: HIV prevalence and correlates of risk for men who have sex with men, transgender women in multiple cities in Papua New Guinea

BMC Public Health, 2019
Background Biobehavioral data about men who have sex with men (MSM) and transgender women (TGW) in Papua New Guinea (PNG) are limited to those who sell sex.
Avi J. Hakim, Kelsey Coy, Steven G. Badman, Barne Willie, Rebecca Narokobi, Josephine Gabuzzi, Simon Pekon, Martha Kupul, Parker Hou, Herick Aeno, Ruthy Neo Boli, Joshua Nembari, Sophie Ase, Angelyne Amos, Nick Dala, Damian Weikum, Steven Callens, John M. Kaldor, Andrew J. Vallely, Angela Kelly-Hanku, on behalf of the Kauntim mi tu Study Team   +20 more
doaj   +1 more source

Waveguide Photoactuators: Materials, Fabrication, and Applications

Advanced Robotics Research, EarlyView.
Waveguide photoactuators convert guided light into mechanical motion. Their tethered‐flexible design enables minimally invasive surgery and confined‐space robotics. This review aims to guide materials selection, device design, and system integration, accelerating the transition of waveguide photoactuators from laboratory prototypes to versatile ...
Minjie Xi, Hemin Pan, Yang Zong, Yongfeng Mei, Jizhai Cui   +4 more
wiley   +1 more source

Reimagining conservation practice: Indigenous self-determination and collaboration in Papua New Guinea

Oryx, 2023
Here we describe a 14-year collaboration in New Ireland, Papua New Guinea, between an Indigenous NGO, Indigenous scientists and international researchers.
John Aini, Paige West, Yolarnie Amepou, Michael Ladi Piskaut, Cornelius Gasot, Rachel S. James, Jason Steadman Roberts, Patrick Nason, Anna Elyse Brachey   +8 more
doaj   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Risk factors and pregnancy outcomes associated with placental malaria in a prospective cohort of Papua New Guinean women

Malaria Journal, 2017
Background Plasmodium falciparum in pregnancy results in substantial poor health outcomes for both mother and child, particularly in young, primigravid mothers who are at greatest risk of placental malaria (PM) infection.
Elvin Lufele, Alexandra Umbers, Jaume Ordi, Maria Ome-Kaius, Regina Wangnapi, Holger Unger, Nandao Tarongka, Peter Siba, Ivo Mueller, Leanne Robinson, Stephen Rogerson   +10 more
doaj   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Continuous quality improvement in a community-wide TB screening and prevention programme in Papua New Guinea

Public Health Action
SETTING: Daru Island in Papua New Guinea (PNG) has a high prevalence of TB and multidrug-resistant TB (MDR-TB). OBJECTIVE: To evaluate the early implementation of a community-wide project to detect and treat TB disease and infection, outline the decision-
N.P. Pank, A. Aung, G. Kama, A. Murray, K.L. Huang, J. Greig, M. Bauri, G. Chan, C. Masah, K. Kaison, S. Umali, T. Peter, C. Wera, C. Velaki, M. Ase, I. Krangaie, R. Viru, T. Kurumop, T. Keam, S. Islam, W. Pomat, A. Maha, M. Boga, M. Kal, N. Wuatai, S.M. Graham, S.S. Majumdar, T. Marukutira   +27 more
doaj   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source