Results 241 to 250 of about 18,947,172 (304)

The Discovery Research Platform for Medical Humanities responds to the Wellcome Trust's report on <i>Archives, manuscripts and material culture (AMCs) in life, health, and wellbeing research</i>. [PDF]

Wellcome Open Res
Barratt H, Johnstone F, McGuire C.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Career outcomes of PhD holders in Africa: Protocol for a scoping review. [PDF]

PLoS One
Haley A, Haybano AK, Wärvik GB.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Cultivating medical humanistic literacy through immersive case-based practical teaching in undergraduate pathophysiology education. [PDF]

Front Med (Lausanne)
Lai X, Shen Y, Zhang R, Peng H, Wang Y, Le Y, Yang X, Zhang D, Wei L.   +8 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

<i>Cambridge Prisms: Extinction</i>, after 4 years. [PDF]

Camb Prism Extinct
Brook BW, Alroy J.
europepmc   +1 more source

Comment on: 'Livestock farmers' knowledge, attitudes and practices relating to zoonoses in the Coastal Savannah zone of Ghana'. [PDF]

Int Health
Davey G.
europepmc   +1 more source

Structural characteristics of research ethics committees in Japan and their relevance to regulatory science: a nationwide descriptive study. [PDF]

BMC Med Ethics
Hara T, Iwahara Y, Murakawa S.
europepmc   +1 more source