Results 181 to 190 of about 93,480 (289)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Implementing Population Health Management (PHM) Across an Integrated Care System in England, Using Action Learning Sets and an Embedded, Formative Process Evaluation. [PDF]

Int J Integr Care
Elston J, Gradinger F, Bockarie T, Tomblin K, Snaith G, Byng R, Asthana S.   +6 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Late Acheulian stone-working by the riverbank: Patterns of continuity and change reflected in Jaljulia lithic assemblages, Israel. [PDF]

PLoS One
Rosenberg-Yefet T, Agam A, Assaf E, Efrati B, Kedar Y, Litov V, Shemer M, Barkai R.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Spatial Patterns of Intraspecific Genetic Diversity Follow no General Rule Across Climatic and Geographic Gradients. [PDF]

Mol Ecol
Moreira MO, Paúl MJ, Liz AV, Carnaval AC, Carstens BC, Carvalho SB.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The destruction of Gaza: Satellite measurements of the economic cost of war. [PDF]

PNAS Nexus
Rinaldo D, Alazzeh R, Arcand JL, Scher C, Van Den Hoek J.   +4 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Asymptomatic and submicroscopic Plasmodium vivax infection: a study previous to malaria-free certification in Argentina. [PDF]

Malar J
Dantur-Juri MJ, Coello-Peralta RD, Calle-Atariguana DE, Arevalo-Bozada MM, Duque PL, González-Piñeres N, Rougeron V, Degrugillier F, Dentice-Maidana S, Liria-Salazar J, Zaidenberg MO.   +10 more
europepmc   +1 more source