Results 41 to 50 of about 1,760,261 (267)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Current Biology, 1996 Time was when scientists didn't need to track many media to know how science was being presented to the public. True science buffs read magazines like Science News or Scientific American, or watched Jacques Cousteau specials on TV. But the average person heard only about sensational discoveries and was rarely exposed to how research was done or what ...
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Journal of Engineering and Applied ScienceThe research presents a Hybrid Fuzzy–Predictive Co-Regulation Model (HF-PCM) as a solution for enhancing adaptive human–system interaction within virtual environments. The framework uses a Sugeno-type fuzzy inference system together with Model Predictive
Han Yan +3 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Frontiers in MedicineBackgroundOut-of-pocket expenditure (OOPE) on medicines constitutes a substantial component of healthcare spending in India, particularly among patients with chronic diseases requiring continuous treatment.
Deepak Kumar Vaishnav +9 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Attitudes towards AI: measurement and associations with personality
Scientific ReportsArtificial intelligence (AI) has become an integral part of many contemporary technologies, such as social media platforms, smart devices, and global logistics systems. At the same time, research on the public acceptance of AI shows that many people feel
Jan-Philipp Stein +4 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
SAGE OpenPrevious studies have shown that the fear of missing out (FoMO) is positively associated with social media fatigue. However, few studies have explored the mediating and moderating mechanisms behind this association.
Xinzhou Xie, Guangyao Jin, Qiyu Bai
doaj +1 more source