Results 141 to 150 of about 4,232,965 (395)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Research on the Ideological Politics Education of College Students from the Perspective of New Media
, 2020 Kaiwen Zhu
openalex +2 more sources
New Media – New Educative Challenges for Catechesis
Roczniki Teologiczne, 2018 The development of the Internet and modern communication tools is the subject of research of various scientific disciplines. For many years, polish researchers have been conducting both quantitative and qualitative studies on the degree of Internet use and the impact of new technologies and their tools on the contemporary young generation. The Catholic
openaire +1 more source
Sharing and reusing rich media: lessons from The Open University [PDF]
, 2011 OpenCourseWare and Open Educational Resources comprise many types of assets including rich media. However dynamic rich media offer different opportunities and challenges for learners, teachers and higher education institutions alike than do more static ...
Lane, Andrew, Law, Andrew
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Playing public health: building the HIVe [PDF]
, 2012 In thinking through the impact of digital media on how frontline workers, activists, practitioners and researchers understand and fight HIV and AIDS, it is important to acknowledge that digital media does not only provide new channels and strategies for ...
Apperley, Thomas, Walsh, Christopher S.
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Research on the Quality Improvement of Ideological and Political Education in Colleges and Universities Against the Background of New Media [PDF]
, 2018 Li Zhen
openalex +1 more source