Results 151 to 160 of about 4,232,965 (395)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Humanities & Social Sciences CommunicationsOne important feature of newspaper editorials concerns the presentation of opposing values towards one ideational entity. This study aims to explore affiliation around contrasting values in media discourse, with a particular focus on the role of counter ...
Feifei Liu, Wei He, Michele Zappavigna
doaj +1 more source
Галактика медиа: журнал медиа исследованийIn the context of rapidly evolving digital technologies, the dissemination of information in new media is accompanied by a number of challenges, including the proliferation of disinformation, fake news, and information pollution.
Burak Ili
doaj +1 more source
Research on the innovation path of breaking the cocoon effect of ideological and political education information in colleges and universities in the new media era [PDF]
J F Su
openalex +1 more source
[Retracted] Problems and Measures of Traditional Culture Education and Mental Health Education in Colleges and Universities under the New Media Environment [PDF]
, 2022 Zheng Xiang, Junxiao Bao, Jinli Wang
openalex +1 more source
Estimating the Importance of Social Media in Consumers’ Education and Information Using New Techniques [PDF]
The social media is composed of easily accessible web tools through which people converse, participate, create, recommend, valorify information and respond online to everything that happens around them. These web tools offer a dynamic virtual environment
Cristian Bogdan Onete +2 more
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