Results 81 to 90 of about 1,831,272 (350)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

New Media and the Development of Education Sector

open access: yesSAGE Open, 2016
This study appraised the use of the new media by students in Obio/Akpor Local Government Area of Rivers State, Nigeria. The objectives of the study were to identify extent of use of new media and to find out challenges experienced while using new media ...
Aniefiok J. Udoudo, Gbemisola O. Ojo
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Physical education down under: Fusion or confusion

open access: yes, 2007
At the International Council for Health, Physical Education, Recreation, Sport and Dance (ICHPER-SD) Conference held in Wellington in October 2006, the authors presented a keynote titled: Physical Education Down Under: Fusion or Confusion.
Culpan, Ian, Grant, Bevan C.
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Reflections on rural education in the frame of Communication-Education [PDF]

open access: yesCivilizar, 2008
The Colombian rural life is energized by its unique forms of production,peculiar traditions, cultural forms and its special knowledge. Consequently, rural education acquires a complexity because of these and other categories, which is why the teaching ...
Óscar Julián Cuesta Moreno
doaj  

Digital culture in the light of educational processes. Ad vocem for the remarks and musings of Jordan Shapiro concerning the digital childhood [PDF]

open access: yesStudia z Teorii Wychowania
Digital technologies not only reshape the ways we experience the world but also redefine intergenerational relationships and fundamental educational mechanisms.
Łukasz Androsiuk, Małgorzata Obrycka
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Key competencies: Views from the gym floor.

open access: yes, 2008
The release of The New Zealand Curriculum (2007) will inevitably yield challenges and possibilities for teachers of Physical Education in both primary and secondary schools.
Gillespie, Lorna B.
core  

Teaching new media composition studies in a lifelong learning context [PDF]

open access: yes, 2000
Governmental proposals for lifelong learning, and the role of Information and Learning Technologies/Information Communication Technologies (ILT/ICT) in this, idealistically proclaim that ILT/ICT empowers learners.
David Squires   +3 more
core   +1 more source

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