Results 1 to 10 of about 2,058 (159)

Genetics of Response to Canagliflozin (GRC) Study: Rationale, Design, and Pharmacodynamic Responses. [PDF]

Clin Transl Sci
ABSTRACT Sodium glucose cotransporter‐2 (SGLT2) inhibitors are a class of antidiabetics with benefits including HbA1c‐lowering, weight loss, cardiovascular and renal protection in addition to adverse effects including genitourinary tract infections, ketoacidosis, and bone loss.
Montasser ME, Bargal SA, Streeten EA, Whitlatch HB, Yazdi ZS, Sirody J, Kiplagat R, Beshara M, O'Connell JR, Taylor SI, Beitelshees AL.   +10 more
europepmc   +2 more sources

Pathogenic Variants in Mennonites From Southern Brazil: Implications for Preventive Measures in Public Health. [PDF]

Clin Genet
In 325 exomes of South Brazilian Mennonites, we identified 23 pathogenic variants (P) and 27 likely P, with founder effects identified for 96% of P, whose frequencies differed from non‐Finnish Europeans, Amish, and Brazilian populations. ABSTRACT The Mennonite population has a unique history of 500 years of genetic isolation shaped by at least three ...
Mayer de Lima LB, Auer ED, Dall'Oglio Bucco I, Hoch VB, Dos Santos PI, Lopes FL, Shuldiner A, Júnior EL, Boldt ABW.   +8 more
europepmc   +2 more sources

Examining Atopic Dermatitis Through the One Health Concept Lens. [PDF]

Allergy
ABSTRACT This paper explores the application of the One Health framework to atopic dermatitis (AD), a complex, chronic skin disease, emphasizing interdisciplinary approaches to prevention and management. One Health integrates human, animal, environmental, and plant health, addressing challenges such as antimicrobial resistance, infectious diseases, and
Minić-Pantić D, Abela B, Lehtimäki J, Zink A, Jensen-Jarolim E, Fettelschoss-Gabriel A, Traidl-Hoffmann C, Ring J, Schmid-Grendelmeir P, Prélaud P, Taïeb A.   +10 more
europepmc   +2 more sources

A new genetic syndrome among the Old Order Amish of Smicksburg Pennsylvania [PDF]

Genetics in Medicine, 2000
The Old Order Amish are a religious sect well known for their simple way of life and are of interest to geneticists due to the unique opportunity they provide for the study of genetic diseases. The Old Order Amish have a high rate of consanguinity and therefore have a higher proportion of recessive genetic conditions than non-Amish populations. We have
G.L. Matika, M.A. Del Vecchio, C.A. Bay
openaire   +1 more source

Locke(d) in a Dilemma: The Problem of Territorial Authority

Philosophy &Public Affairs, EarlyView.
ABSTRACT In Lockean social contract theory, the state exercises its authority over territory through property rights. The state has territorial authority over the property it and its citizens claim. This authority is legitimate when the state has the consent of the governed and effectively governs. In this paper, I argue that there is an irreconcilable
Samantha L. Fritz
wiley   +1 more source

Genetic Linkage for Bipolar Disorder to the Distal Region of Chromosome 19q: A Large Family Whole Genome Sequencing Study

Bipolar Disorders, Volume 28, Issue 4, June 2026.
ABSTRACT Background Bipolar disorder (BD) is among the most heritable psychiatric disorders, with a genetic architecture likely consisting of both common genetic variants with small effects and rare variants with strong effects in certain families or populations.
Albert H. C. Wong, Andrew D. Paterson, Nicole M. Roslin, Elizabeth Tetzlaff, Andrew B. Sedrak, Young Zhou, Gaurav Sharma, Paul Grof, Anne Duffy   +8 more
wiley   +1 more source

Synaptic biomarkers in Alzheimer's disease dementia and mild cognitive impairment: A systematic review and meta‐analysis

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by synaptopathy, a neuropathological feature that can contribute to underlying cognitive decline. Here, we evaluate potential cerebrospinal fluid (CSF) and blood‐based synaptic biomarkers in AD dementia and its earliest clinical stage, mild cognitive impairment (MCI). METHODS Articles that
Amish Gaur, Melissa Wong, Jinghan Jenny Chen, Yejin Kang, Danielle Tahoulas, Komalpreet Jeor, Keeirah H. Raguram, Damien Gallagher, Mark Rapoport, Nathan Herrmann, Krista L. Lanctôt   +10 more
wiley   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Constitutive Disorder As Method: A Multilingual Dictionary From Within the Camp

Population, Space and Place, Volume 32, Issue 4, May 2026.
ABSTRACT This article analyzes Multilingual Dictionary – Living Together in a Refugee Camp, a co‐research project documenting words and expressions created, invented, and circulated among migrant communities in the Moria and Mavrovouni camps on Lesvos Island between 2018 and 2022.
Nagehan Uskan
wiley   +1 more source

Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Despite the identification of familial Alzheimer's disease (FAD) genes and neuropathological alterations, AD displays complex genetic heterogeneity and molecular pathogenesis that warrant further investigation. GBF1 (Golgi brefeldin A resistant guanine nucleotide exchange factor 1) regulates protein trafficking, and genetic ...
Sean J. Miller, Dmitry Prokopenko, Ping Bai, Prasenjit Mondal, Abigael Scott, Wei Zhang, Ashley Gomm, Siyi Zhang, Daniel D. Child, Nolan Shen, Joseph Ward, Scott Schulte, Dan Lei, Brian P. Hafler, Changning Wang, Rudolph E. Tanzi, Can Zhang   +16 more
wiley   +1 more source