Results 101 to 110 of about 7,059,453 (271)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Interfacial modulation of alkaloid release pathways in aqueous-polyol solvents: Protonation-dependent vaporization kinetics

open access: yesResults in Chemistry
The release efficiency of alkaloids (e.g. nicotine) in aerosol-generating systems is strongly influenced by solvent-mediated molecular interactions at interfaces.
Ying He   +10 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

To really know them you have to grow them

open access: yesBioingeniøren, 2017
Background: Only a small fraction of bacteria in complex environmental samples, such as soil, water and sediments can at present be grown on synthetic media under laboratory conditions.
Colin Charnock   +2 more
doaj  

Implications of the Propagation Method for the Phytochemistry of Nepeta cataria L. throughout a Growing Season

open access: yesMolecules
Catnip (Nepeta cataria L.) plants produce a wide array of specialized metabolites with multiple applications for human health. The productivity of such metabolites, including nepetalactones, and natural insect repellents is influenced by the conditions ...
Erik Nunes Gomes   +6 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Romvac: proiecte și produse noi [PDF]

open access: yesMedicamentul Veterinar, 2018
Time has proved so far that all steps taken by Romvac SA in veterinary medicine and as new in the human medicine, were highly inspired, the result of actions initiated at the right time and the right place.
Constantin Chiurciu
doaj  

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