Results 51 to 60 of about 30,079,203 (307)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Towards Excellence in Public Administration Education and Training: an African and South African Experience [PDF]
, 2014 Not only did globalization bring about profound changes to public administration worldwide, but it also challenged the implementation of the New Public Management (NPM) paradigm in terms of service delivery, posing the question whether public ...
Kroukamp, Hendri
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Achieving equality in progressive contexts: queer(y)ing public administration [PDF]
, 2020 In many countries, including the UK, the majority of legal impediments to equality for LGBT+ people have been removed, and legislation actively promotes equality for LGBT+ people.
Poyner, Chris, Matthews, Peter
core
The never-ending story of public administration reform in Slovenia (from 1991 to further development) [PDF]
, 2014 In Slovenia, the public administration reform has been a systematic task since 1996 when the government adopted the strategy of transformation of public administration due to Slovenia becoming a full member of EU.
Kovač, Polona
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Ler História, 2009 Between 1960 and 1968, the Portuguese government managed modernization, economic growth and trade openness to Europe in an ambiguous way. This processes that profoundly transformed the society have not been politically accepted.
Victor Pereira
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Health Care Reforms, Power Concentration, and Receding Citizen Participation
Risk Management and Healthcare Policy, 2023 Daniel Simonet Department of Management, Strategy & Entrepreneurship, American University of Sharjah, Sharjah, United Arab EmiratesCorrespondence: Daniel Simonet, Email dsimonet@aus.eduAbstract: The article highlights several outstanding features of ...
Simonet D
doaj