Results 41 to 50 of about 109,007 (259)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Revista Enfoques, 2009 This text aims at accounting for the evolution of the reform movement that goes from Public Administration to Governance, while going through New Public Management.A movement that to be understood requires, more than a sequence of steps, the ...
André Azevedo Alves +1 more
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Journal of Current Southeast Asian Affairs, 2022 International stakeholders working with domestic entities to co-produce new institutions of economic governance are common in developing settings such as Myanmar.
Phone Pyae Soe +2 more
doaj +1 more source
Public and Nonprofit Management and the “New Governance” [PDF]
The American Review of Public Administration, 2008 Many public functions originally performed primarily by state actors now routinely rest not with the responsible government agencies but with a host of nongovernmental, third-party surrogates or proxies. There has also been an increase in partnerships and collaboration between nonprofits, corporations, and governments, necessitating new skills and ...
Leda McIntyre Hall, Sheila Suess Kennedy
openaire +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Transformation of Public Administration in the Context of Contingent Social Systems
RUDN Journal of Political ScienceThis study examines the transformation of public administration theory and practice in the new context of contingent social systems. The relationship between the bifurcation development of modern society and trends in administrative reforms is determined.
Leonid V. Smorgunov
doaj +1 more source