Results 41 to 50 of about 976,347 (249)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Performance Management Systems Productivity in the Public Sector: Wither African Public Administration

open access: yesAfrica’s Public Service Delivery & Performance Review, 2014
Performance management has attracted a lot of debate in the recent past. It is a systematic effort to improve performance through an ongoing process of establishing desired outcomes, setting performance standards to improve performance and productivity ...
Jacob Olufemi Fatile
doaj   +1 more source

Estimating the cost of implementing a facility and community score card for maternal and newborn care service delivery in a rural district in Uganda

open access: yesInternational Journal for Equity in Health, 2021
Introduction This paper aimed at estimating the resources required to implement a community Score Card by a typical rural district health team in Uganda, as a mechanism for fostering accountability, utilization and quality of maternal and child ...
Anthony Ssebagereka   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

New Public Management – Public Policy for Institutional Reforms

open access: yesActa Economica et Turistica, 2021
The New Public Management model contains public policies for market-driven institutional reforms. Countries that applied this model are generally among the TOP 20 in global rankings concerning human development, human freedom, economic freedom, ease of ...
Daniel Hinšt
doaj  

Penjajagan Awal Penerapan 'New Public Management' dalam Administrasi Kabupaten

open access: yesJSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2002
The popularity of New Public Management in the developed countries raises a question whether such a concept applicable in the Third World context. Relies on three focuses group discussion involving local bureaucrats, this article shows the desirability ...
Samodra Wibawa
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Explanation and Pathology of the Current Pattern of Public Administration in Iran [PDF]

open access: yesمدیریت دولتی, 2019
Objective:The purpose of this study is to illustrate the process of applying the “new public management” approach in the country, the reasons for its inefficiencies, as well as its consequences.
Hadi Mohammadzadeh Soltanmoradi   +3 more
doaj   +1 more source

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