Results 101 to 110 of about 1,374,901 (307)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Rejecting the Radical New Left: Transformations in Japanese Social Movements

SocietàMutamentoPolitica: Rivista Italiana di Sociologia
After a disastrous period of New Left political violence in the late 1960s and early 1970s, followed by two decades of abeyance, Japan has experienced a renewed era of social movement activity since the 1990s. These new movements explicitly seek to avoid
David H. Slater, Patricia G. Steinhoff
doaj   +1 more source

New Social Problems and Social Movements

Japanese Sociological Review, 2006
This paper tries to answer two questions. First, what kind of social movement is especially needed under individualization? Second, can we empirically find appropriate theoretical movements? To answer the first question, I view arguments about individualization and confirm statements about an intolerable burden on individuals to reflexively construct ...
openaire   +2 more sources

Social and Environmental Attributes of Food Products in an Emerging Mass Market : Challenges of Signaling and Consumer Perception, With European Illustrations [PDF]

This paper focuses on the environmental and ethical attributes of food products and their production processes. These two aspects have been recently recognized and are becoming increasingly important, in terms of signaling and of consumer perception ...
Jean-Marie Codron, Lucie Sirieix, Thomas Reardon   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Los nuevos movimientos sociales reencantan el mundo [PDF]

, 2017
El artículo propone revisar los análisis convencionales sobre los nuevos movimientos sociales con la propuesta de que es necesario incorporar la dimensión afectiva o de adhesión emocional, sin la que, a nuestro juicio, difícilmente puede comprenderse la ...
Hernández-Ramírez, Javier, Talego Vázquez, Félix   +1 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

How European Protest Transforms Institutions of the Public Sphere - Discourse and Decision-Making in the European Social Forum Process [PDF]

Against the background of the alleged democratic deficit of EU institutions, this case study explores how politicization and emerging transnational public spaces in European protest movements innovate existing practices of discursive or grassroots ...
Nicole Doerr
core  

Social movements in world of warcraft [PDF]

, 2011
Virtual worlds provide new forms of social interaction. They offer alternative spaces where social functions can be carried out in online three-dimensional virtual environments.
Gardner, L, Mckenna, Brad, Myers, M
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source