Results 91 to 100 of about 2,973,028 (319)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A new species of Gyrodactylus (Monogenea, Gyrodactylidae), an ectoparasite from the endemic Iranocichla hormuzensis (Teleostei, Cichlidae), the only Iranian cichlid

, 2012
Iranocichla hormuzensis occupies a biogeographically peculiar position. This endemic of southern Iran is the only Iranian cichlid. While it is phylogenetically related to African oreochromine members of the cichlid family, it remains unclear how it has ...
Maarten P.M. Vanhove, Tine Huyse, Boeger, W.A., Muterezi Bukinga, F., Walter A. Boeger, Vanhove, M.P.M., Fidel Muterezi Bukinga, Huyse, Tine, Antoine Pariselle, Bukinga, Fidel Muterezi, Vanhove, Maarten P. M., Boeger, Walter A., Pariselle, Antoine, Volckaert, Filip A. M., Vanhove, Maarten P.M., Filip A.M. Volckaert, Volckaert, F.A.M., Muterezi Bukinga, Fidel, Volckaert, Filip A.M., Huyse, T.   +19 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Cross‐Validation of Diet Determination Methods for Seabird Conservation

Environmental DNA
Seabirds are recognized as one of the most vulnerable groups of birds, with around a third of species identified as globally threatened. The conservation of seabirds is often linked with their feeding and diet, due to undesirable interactions with human ...
Aimee L. van derReis, Chris Lalas, Rob Schuckard, Karen L. Middlemiss, Andrew G. Jeffs   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Capalictus, a new subgenus of Lasioglossum Curtis, 1833 from South Africa, with description of three new species (Hymenoptera, Apoidea, Halictidae)

, 2012
Capalictus, a new subgenus of Lasioglossum Curtis, 1833 (Hymenoptera, Apoidea, Halictidae), endemic to the South African Cape Province, is described. The type species is Halictus mosselinus Cockerell, 1945. Evylaeus (Sellalictus) fynbosensis (Pauly et al.
Gibbs, Jason, Michael Kuhlmann, Kuhlmann, Michael,, Alain Pauly, Kuhlmann, Michael, Pauly, Alain, Jason Gibbs   +6 more
core   +1 more source

A review of the genus Stephanorhynchus White, 1846 (Coleoptera: Curculionidae: Eugnomini), with a description of three new genera and one new species from New Zealand

The European Zoological Journal
Stephanorhynchus White, 1846 is a eugnomine weevil genus endemic to New Zealand, with 18 nominal taxa described within the genus. Examination of the type specimens of these taxa with greater understanding of related genera has led to the distinction of ...
M. A. Mazur, S. D. J. Brown
doaj   +1 more source

A NEW SPECIES OF NEONYMPHA [PDF]

The Canadian Entomologist, 1889
Neonympha Mitchellii n. sp.Male.—Upper surface grayish wood-brown, rather dark, without spots or marks, except that the spots on the underside of the hind wings and the dark lines bordering the terminal dark yellow line on the same wings show through a little. Fringes concolorus, in certain lights a little smoky tinged.
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

On the Neotropical species of the spider genus Tekellina Levi, 1957 (Arachnida: Araneae: Synotaxidae)

European Journal of Taxonomy
The genus Tekellina Levi, 1957 is currently composed of ten species, six of which are Neotropical. They are small-sized spiders (0.9 to 1.5 mm), with a wide distribution, with a great diversity in the Neotropical Region and well represented in Brazil ...
Narelle Estol, Victor Hugo Valiati, Antonio D. Brescovit, Everton Nei Lopes Rodrigues   +3 more
doaj   +1 more source