Results 71 to 80 of about 22,713,750 (361)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Cross‐Validation of Diet Determination Methods for Seabird Conservation

Environmental DNA
Seabirds are recognized as one of the most vulnerable groups of birds, with around a third of species identified as globally threatened. The conservation of seabirds is often linked with their feeding and diet, due to undesirable interactions with human ...
Aimee L. van derReis, Chris Lalas, Rob Schuckard, Karen L. Middlemiss, Andrew G. Jeffs   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Summer and winter habitat suitability of Marco Polo argali in southeastern Tajikistan: A modeling approach

Heliyon, 2017
We modeled summer and winter habitat suitability of Marco Polo argali in the Pamir Mountains in southeastern Tajikistan using these statistical algorithms: Generalized Linear Model, Random Forest, Boosted Regression Tree, Maxent, and Multivariate ...
Eric Ariel L. Salas, Raul Valdez, Stefan Michel   +2 more
doaj   +1 more source

Analysing ecological networks of species interactions

Biological Reviews of The Cambridge Philosophical Society, 2018
Network approaches to ecological questions have been increasingly used, particularly in recent decades. The abstraction of ecological systems – such as communities – through networks of interactions between their components indeed provides a way to ...
E. Delmas, M. Besson, Marie‐Hélène Brice, L. Burkle, Giulio V. Dalla Riva, M. Fortin, D. Gravel, P. Guimarães, David H. Hembry, Erica A. Newman, J. Olesen, M. Pires, J. Yeakel, T. Poisot   +13 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Boundary spanning increases knowledge and action on invasive species in a changing climate

Ecological Solutions and Evidence
Challenges associated with global change stressors on ecosystems have prompted calls to improve actionable science, including through boundary‐spanning activities, which aim to build connections and communication between researchers and natural resource ...
Annette E. Evans, Eva M. Colberg, Jenica M. Allen, Evelyn M. Beaury, Carrie Brown‐Lima, Toni Lyn Morelli, Bethany A. Bradley   +6 more
doaj   +1 more source

A review of the genus Stephanorhynchus White, 1846 (Coleoptera: Curculionidae: Eugnomini), with a description of three new genera and one new species from New Zealand

The European Zoological Journal
Stephanorhynchus White, 1846 is a eugnomine weevil genus endemic to New Zealand, with 18 nominal taxa described within the genus. Examination of the type specimens of these taxa with greater understanding of related genera has led to the distinction of ...
M. A. Mazur, S. D. J. Brown
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source