Results 111 to 120 of about 5,260,738 (315)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

JCA Eni ENEA Project: CSP & Thermal Storage

open access: yesSolarPACES Conference Proceedings
This project is framed inside a three-year-long cooperation between Eni and ENEA. It concerns the development of prototypes, technologies, innovative processes, feasibility studies, scenario analysis, exchanging skills, and know-how.
Raffaele Liberatore   +9 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Fabrication and Properties of Axially Compressed Isotropic Epoxy-Bonded NdFeB Magnets with Partial Rare-Earth Substitution

open access: yesMicro
This work investigates the fabrication and performance of axially compressed isotropic epoxy-bonded NdFeB-type magnets produced from melt-spun powders with partial substitution of (Nd,Pr) by (La,Ce). Four alloy compositions were synthesized and processed
Evangelia Dimeli   +4 more
doaj   +1 more source

Effect of the Micro Wire-EDM Process Parameters on the Recast Layer in the Molybdenum Micromachining [PDF]

open access: yesInternational Journal of Advanced Design and Manufacturing Technology, 2017
The Micro wire electrical discharge machining (Micro wire-EDM) process is a modern machining process with various applications in manufacturing micro-parts. The recast layer remaining on the machined surfaces is an inevitable complication of this process.
Mohammad Tahmasebipour   +3 more
doaj  

The Financing and Governance of New Technologies [PDF]

open access: yes
This paper examines the financial sector preconditions for the successful development of high technology sectors. It argues that there is a close relation between types of activities undertaken in different countries and their institutional structures. A
Mayer, Colin
core  

Community-based mentoring and innovating through Web 2.0 [PDF]

open access: yes, 2009
The rise of social software, often termed Web 2.0, has resulted in heightened awareness of the opportunities for creative and innovative approaches to learning that are afforded by network technologies.
Costa, Cristina, Keegan, Helen
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

BOOK REVIEW: ADRENALINE JUNKIES AND TEMPLATE ZOMBIES Understanding Patterns of Project Behavior by Tom Demarco, Peter Hruschka, Tim Lister, Steve McMenamin, James Robertson, Suzanne Robertson [PDF]

open access: yesJournal of Defense Resources Management, 2016
Today, armed forces are in continuous transformation. As new technologies are developed and new principles of war are introduced, the ministries of defenses and armed forces have to adapt to this changing environment. Almost every day, military officials
DR. KADIR ALPASLAN DEMIR
doaj  

New technologies

open access: yesCurrent Opinion in Neurobiology, 2005
Miesenböck, G, Morris, R
openaire   +2 more sources

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