Results 51 to 60 of about 5,198,158 (308)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium

Communications Biology
The efficient transport of proteins into the primary cilium is a crucial step for many signaling pathways. Dysfunction of this process can lead to the disruption of signaling cascades or cilium assembly, resulting in developmental disorders and cancer ...
S. M. Niedziółka, S. Datta, T. Uśpieński, B. Baran, W. Skarżyńska, E. W. Humke, R. Rohatgi, P. Niewiadomski   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Litigation and new technologies in post-conventional societies [PDF]

, 2012
The increase in the volume of litigation verified since the 1990’s, having the Brazilian society as context, made the judiciary open itself to new technologies which facilitate the access to justice, as well as to a faster resolution of the demands ...
Bannwart Junior, Clodomiro José, Oléa, Carlos Frederico   +1 more
core  

The effect of new technologies on civic participation models [PDF]

, 2018
The development of new technologies will enable decentralization and freedom of communication for large numbers of people, by overcoming the barriers that once rendered direct participation of society unfeasible.
Holubiak, Nataliia
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Method for emissivity measurement of semitransparent coatings at ambient temperature

Scientific Reports, 2017
Coatings deposited on a material surface are effective way of changing its surface properties. For increasing or decreasing radiation heat transfer, coatings with high or low emissivity are used.
Petra Honnerová, Jiří Martan, Zdeněk Veselý, Milan Honner   +3 more
doaj   +1 more source

Comparison of E. coli based self-inducible expression systems containing different human heat shock proteins

Scientific Reports, 2021
IPTG-inducible promoter is popularly used for the expression of recombinant proteins. However, it is not suitable at the industrial scale due to the high cost and toxicity on the producing cells.
Fatemeh Sadat Shariati, Malihe Keramati, Vahideh Valizadeh, Reza Ahangari Cohan, Dariush Norouzian   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The shift from Media Art to the Future Art-Design-Think-Tank

Lumina, 2017
In the coming decades, new technologies will change our lives and the way in which we perceive them in hitherto unimaginable ways.Future Design is acreative collusion of science, technology and art– an experimental laboratory for new art forms and ...
Ludger Pfanz
doaj   +1 more source