Results 71 to 80 of about 1,441,615 (268)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Analysis and validation of CFD simulations for flow in the large power station flue gas system [PDF]

EPJ Web of Conferences
This paper deals with complex CFD simulations of flows in the flue gas system of a large power plant during operation. The aim of the published results is to present generalising knowledge obtained from complex simulations in the power station and show ...
Matas Richard, Kňourek Jindřich, Novák Martin   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Regulation of new technologies and new technologies in regulation

International Journal of Digital Law, 2020
O artigo trata das novas tecnologias e sua relação com o direito administrativo, especialmente no campo da regulação estatal. Inicialmente, apresentam-se as tecnologias por uma classificação setorial. Em seguida, abordam-se as tecnologias como objeto de estímulo, de demanda, de controle e de uso pela Administração Pública.
Thiago Marrara, Gustavo Gil Gasiola
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Evaluating the Cosmetic Efficacy of Topical Micrococcus luteus Q24 Probiotic Balm: A Pilot Study in Healthy Adults

Cosmetics
The skin microbiome is a focus for innovative skincare. This study investigated topical semi-solid balm formulations of Micrococcus luteus Q24, a live skin-native probiotic, to enhance skin quality parameters such as hydration, pores, pigmentation ...
Abigail L. Voss, Stephanie A. Mattison, Sonali S. Sali, John D. F. Hale, Rohit Jain   +4 more
doaj   +1 more source

New reproductive technologies

Best Practice & Research Clinical Obstetrics & Gynaecology, 1999
The ethical calculus is described. There are four entities that have a stake in all ethical decisions. These are the individual, family, community and society at large. Values assigned to these entities can be modified by experience, cultural background, religious authority and the law. In the simple case of in vitro fertilization (IVF), there seems to
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

DIGITAL SCREEN DEVICE AND INTERNET USE AND SLEEP DISTURBANCES: A SYSTEMATIC REVIEW OF THE EVIDENCE (2014–2020)

PsychTech & Health Journal
This systematic review examines the relationship between new technologies and sleep disorders and the influence of these technologies on sleep quality. To this end, articles published between 2014 and 2021 were selected, which were open access, complete,
Ana Sofia Sousa, Andreia Botelho, Andreia Teixeira, Filipe Wanderley   +3 more
doaj   +1 more source