Results 81 to 90 of about 5,260,738 (315)

The Hira complex regulates Gli3R-dependent transcription in Hedgehog signaling and medulloblastoma cell growth and migration

Scientific Reports
Regulation of the Hedgehog pathway activity may be supported by coactivators and corepresors of its main effectors- Gli transcription factors. While activation processes are well studied, repression mechanisms remain elusive.
Weronika Skarżyńska, Brygida Baran, Paweł Niewiadomski   +2 more
doaj   +1 more source

Analysis and validation of CFD simulations for flow in the large power station flue gas system [PDF]

EPJ Web of Conferences
This paper deals with complex CFD simulations of flows in the flue gas system of a large power plant during operation. The aim of the published results is to present generalising knowledge obtained from complex simulations in the power station and show ...
Matas Richard, Kňourek Jindřich, Novák Martin   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

NEW TECHNOLOGIES IN BIOFUEL PRODUCTION [PDF]

Resource /Energy Economics and Policy,
Bothast, Rodney J.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

New technologies [PDF]

Current Opinion in Neurobiology, 2010
Erin, Schuman, Xiaowei, Zhuang
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evaluating the Cosmetic Efficacy of Topical Micrococcus luteus Q24 Probiotic Balm: A Pilot Study in Healthy Adults

Cosmetics
The skin microbiome is a focus for innovative skincare. This study investigated topical semi-solid balm formulations of Micrococcus luteus Q24, a live skin-native probiotic, to enhance skin quality parameters such as hydration, pores, pigmentation ...
Abigail L. Voss, Stephanie A. Mattison, Sonali S. Sali, John D. F. Hale, Rohit Jain   +4 more
doaj   +1 more source

40 Gbps Access for Metro networks: Implications in terms of Sustainability and Innovation from an LCA Perspective

, 2015
In this work, the implications of new technologies, more specifically the new optical FTTH technologies, are studied both from the functional and non-functional perspectives.
Cheriet, Mohamed, Lemieux, Yves, Moghaddam, Reza Farrahi   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source