Results 141 to 150 of about 90,410 (258)

Technique for Lateral Opening Wedge Distal Femoral Osteotomy Using Patient‐Specific Instrumentation for Genu Valgum and Patellar Instability

Arthroscopy Techniques, EarlyView.
Abstract Recurrent lateral patellar instability poses a technical challenge to orthopaedic surgeons. Isolated soft‐tissue procedures through medial patellofemoral ligament reconstruction or lateral release show unacceptably high failure rates. Lateral opening wedge distal femoral osteotomy addresses underlying bony malalignment and reinforces the soft ...
Alexander P. Decilveo, Elan Karlin, Neil Patel, Allison Ariniello, George F. Rick Hatch   +4 more
wiley   +1 more source

Limited susceptibility of rhesus macaques to a cowpox virus isolated from a lethal outbreak among New World monkeys. [PDF]

Primate Biol, 2017
Mätz-Rensing K, Yue C, Klenner J, Ellerbrok H, Stahl-Hennig C.   +4 more
europepmc   +1 more source

Digital innovation for a greener future: the role of artificial intelligence in Europe's biofuel transition

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract This study investigates the relationship between artificial intelligence (AI) development and biofuel production using a balanced panel dataset of 12 European Union (EU) countries over the 2008–2024 period. Employing feasible generalized least squares (FGLS) estimation with distributed lag specifications, the analysis controls for Renewable ...
Tufan Sarıtaş, Emin Ahmet Kaplan, Yasin Büyükkör, Alper Aslan   +3 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys. [PDF]

BMC Evol Biol, 2016
Tsutsui K, Otoh M, Sakurai K, Suzuki-Hashido N, Hayakawa T, Misaka T, Ishimaru Y, Aureli F, Melin AD, Kawamura S, Imai H.   +10 more
europepmc   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Detection of Mycobacterium tuberculosis Complex in New World Monkeys in Peru. [PDF]

Ecohealth, 2015
Rosenbaum M, Mendoza P, Ghersi BM, Wilbur AK, Perez-Brumer A, Cavero Yong N, Kasper MR, Montano S, Zunt JR, Jones-Engel L.   +9 more
europepmc   +1 more source

Prediction of Human Serum Concentration–Time Profiles of Golimumab and Ustekinumab Using Pharmacokinetic Data From Common Marmosets With Assessment of Anti‐Drug Antibodies

Biopharmaceutics &Drug Disposition, EarlyView.
This study identified new optimal allometric scaling exponents for human PK prediction of monoclonal antibodies with linear PKs from marmoset PK data. In addition, immunogenicity in common marmosets was evaluated following the repeated dose of golimumab and ustekinumab, minimal anti‐drug antibodies were detected.
Ayaka Tajiri, Shogo Matsumoto, Nanami Furukawa, Kensuke Kagiyama, Hiroshi Ikeda, Kazumasa Fukasawa, Hiroki Takano   +6 more
wiley   +1 more source

Human Herpesvirus 1 in Wild Marmosets, Brazil, 2008

Emerging Infectious Diseases, 2011
Camila S. Longa, Sávio F. Bruno, Amaury R. Pires, Phyllis C. Romijn, Leda S. Kimura, Carlos H.C. Costa   +5 more
doaj   +1 more source