Results 41 to 50 of about 1,361,832 (248)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Teatro Pós-dramático e Performance Pós-dramática
Revista Brasileira de Estudos da Presença, 2015 Este ensaio inicia com o conceito de teatro pós-dramático conforme formulado pelo teórico alemão Hans- Thies Lehmann e nele se consideram as obras recentes de vários diretores internacionais relevantes – Ivo van Hove, Punchdrunk, Signa, entre outros ...
Marvin Carlson (The City University of New York – Nova Iorque, Estados Unidos)
doaj
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Valencians to New York. The case of La Marina Alta (1912-1920), de Morrell, Teresa.
Cultura, Lenguaje y Representación, 2019 Review of the book Valencians to New York.
Marian Mestre Segarra
doaj
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Paul Virilio’s dromology and the postmodern city in Don DeLillo’s Cosmopolis
Cogent Arts & Humanities, 2018 Don DeLillo’s Cosmopolis (2003) portrays, among other things, New York as a postmodern city. DeLillo’s fiction above all probes how contemporary American consciousness is largely shaped by the incursion of technology into daily life. In DeLillo’s novels,
Bahareh Bagherzadeh Samani +2 more
doaj +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley +1 more source
Iperstoria, 2018 This article examines renowned yet controversial American photographer Spencer Tunick, whose work has led to numerous arrests, a high profile court-case and finally, success abroad.
Nausikaä El-Mecky
doaj +1 more source