Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR‐F508del Rabbit Model
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk ...
Do‐Yeon Cho +9 more
wiley +1 more source
New Zealand Electronic Health Data for Cardiovascular Research: A Review. [PDF]
Clin EpidemiolMøller AE +5 more
europepmc +1 more source
Establishing enduring goals for education for children and young people aged 0 to 18 [PDF]
This Regulatory Impact Statement (RIS) has been prepared by the Ministry of Education (the Ministry). This RIS provides an analysis of options for establishing an enduring strategic direction for early childhood services and schools.
Ministry of Education (New Zealand)
core
Animal models of chronic thromboembolic pulmonary hypertension
Animal Models and Experimental Medicine, EarlyView.Current animal models of CTEPH. Created using BioRender.com. Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, yet life‐threatening disorder characterized by persistent pulmonary vascular obstruction and elevated pulmonary artery pressure, with progressive remodeling and subsequent right heart failure.
Yong‐Jian Zhu +5 more
wiley +1 more source
Genomics and Discrimination in New Zealand Health and Life Insurance. [PDF]
J R Soc N ZShelling AN +3 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Our study demonstrated that a single bilateral intra‐testicular injection of 50% dextrose (Group A) and 20% mannitol (Group B) solutions cannot serve as chemical sterilizing agents in male rabbits. However, intra‐testicular injection of 0.9% saline (Group C) significantly reduced the seminiferous tubule quality (STQ), seminiferous tubule maturity (STM),
Mohammad‐Javad Gholizadeh +2 more
wiley +1 more source
The Efficacy of COVID-19 Vaccination in Mortality Among Multi-Ethnic Long-Term Care Residents in New Zealand. [PDF]
Australas J AgeingCheung G +10 more
europepmc +1 more source
Development of immunocompetent models for primary and metastatic ER+ breast cancer
Animal Models and Experimental Medicine, EarlyView.This study explores syngeneic, immunocompetent models of ER+ breast cancer in 129S6/SvEv mice, using trackable tumor cells to model both primary tumors and metastasis. The models show promise, while also revealing limitations for studying advanced disease and immune interactions.
Devon M. Bull +5 more
wiley +1 more source
The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin
Annals of Neurology, EarlyView.Objectives The objective of this study was to elucidate differences in the cumulative incidence of Leucine‐rich repeat kinase 2 (LRRK2) p.Gly2019Ser‐related Parkinson's disease (PD; LRRK2‐PD) between ancestries and countries. Methods We included 922 unrelated p.Gly2019Ser variant carriers (affected = 762 and unaffected = 160) from the Global Parkinson ...
Theresa Lüth +14 more
wiley +1 more source
What's Needed for a Migraine Cost-Of-Illness Study in Aotearoa New Zealand: Review of Data Sources and Gaps. [PDF]
J R Soc N ZImlach F +5 more
europepmc +1 more source