Results 241 to 250 of about 916,639 (355)

Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation

Advanced Science, EarlyView.
PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng, Lin Guo, Fan Wang, Qian Zhang, Guoyan Wang, Hefei Huang, Wei Du, Hong An, Yue Yang, Henghui Miao, Peng Zheng, Tingting Chu, Dengke Zhang, Xiaoxue Yan, Xiaoyu Mi, Qian Ma, Weilin Gao, Yushan Li, Song Li, Yong Zhang, Zhenliang Zhu, Yu Wang, Jun Liu, Xu Liu   +23 more
wiley   +1 more source

Small and sick newborn care: Changes in service readiness scoring between baseline and 2023 for 65 neonatal units implementing with NEST360 in Kenya, Malawi, Nigeria, and Tanzania. [PDF]

PLOS Glob Public Health
Penzias RE, Ogero MO, Tillya R, Kassim I, Dosunmu O, Odedere O, Mwaniki H, Ochieng VO, Mochache D, Ngwala SK, Zimba E, Soko GT, Bohne C, Gathara D, Cross JH, Shabani J, Paul C, Shamba D, Masanja H, Salim N, Osuagwu C, Idowu A, Ogueji IA, Tongo O, Okunlola Ogunsola O, Ezeaka VC, Rashid E, Okello G, Wainaina J, Macharia WM, Chiume M, Chalira A, Dube Q, Gicheha E, Molyneux EM, Alooh M, Cousens S, Oden M, Richards-Kortum R, Lawn JE, Ohuma EO.   +40 more
europepmc   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

They will be famous: Multipotent stem cells in breast milk. [PDF]

World J Clin Pediatr
Faa G, Pichiri G, Coni P, Dessì A, Fraschini M, Fanos V.   +5 more
europepmc   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Therapeutic effect of exogenous tumor necrosis factor-stimulating protein 6 intervention on lung injury in newborn rats by intrauterine infection. [PDF]

Sci Rep
Kang QY, Sun ZY, Yuan XZ, Su ZY, Xu DY, Zhu W.   +5 more
europepmc   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

It Takes All of Us: How the Cystic Fibrosis Foundation Is Supporting States in Advancing Cystic Fibrosis Newborn Screening. [PDF]

Int J Neonatal Screen
Dwight M, Faro A.
europepmc   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

COMPLICATIONS OF OBLITERATIVE VERSUS RECONSTRUCTIVE VAGINAL SURGERY FOR PELVIC ORGAN PROLAPSE IN OCTOGENARIANS

Continence, 2023
C Coleman, K Bonasia, D Pascali, A Clancy   +3 more
doaj