Results 31 to 40 of about 975,602 (330)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Psychiatric admission during pregnancy in women with schizophrenia who attended a specialist antenatal clinic

Journal of Psychosomatic Obstetrics and Gynecology, 2019
Objectives: The mental health and wellbeing of pregnant women with schizophrenia is an area of research interest. We aim to explore this relationship particularly in regards to psychiatric admission rates, timing and their associated contributing factors.
Elly Lorraine Harris, Jacqueline Frayne, Suzanna Allen, Kanni Renganathan, Thinh Ngoc Nguyen   +4 more
doaj   +1 more source

Implementing maternal death surveillance and response: a review of lessons from country case studies

BMC Pregnancy and Childbirth, 2017
Background Maternal Death Surveillance and Response (MDSR) implementation is monitored globally, but not much is known about what works well, where and why in scaling up.
Helen Smith, Charles Ameh, Natalie Roos, Matthews Mathai, Nynke van den Broek   +4 more
doaj   +1 more source

Does mobile phone ownership predict better utilization of maternal and newborn health services? a cross-sectional study in Timor-Leste. [PDF]

, 2016
BackgroundIncreasingly popular mobile health (mHealth) programs have been proposed to promote better utilization of maternal, newborn and child health services.
Gu, Jing, Hofstee, Marisa, Mercer, Mary Anne, Nie, Juan, Thompson, Susan, Unger, Jennifer Anna   +5 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Community-based Approach to Intermittent Preventive Treatment for Malaria in Pregnancy in Kisumu, Kenya [PDF]

, 2014
Malaria in pregnancy (MiP) is a significant contributor to maternal and newborn morbidity and mortality. In malaria-endemic countries, especially those in tropical areas of Africa where there is intense transmission of Plasmodium falciparum (P ...

core  

A genetic approach to study the relationship between maternal Vitamin D status and newborn anthropometry measurements: the Vitamin D pregnant mother (VDPM) cohort study [PDF]

, 2020
Purpose Adverse effects of maternal vitamin D deficiency have been linked to adverse pregnancy outcomes. We investigated the relationship between maternal vitamin D status and newborn anthropometry measurements using a genetic approach and examined the ...
Aji, Arif Sabta, Alathari, Buthaina, Erwinda, Erwinda, Lipoeto, Nur Indrawaty, Lovegrove, Julie Anne, Malik, Safarina G., Rasyid, Rosfita, Vimaleswaran, Karani Santhanakrishnan, Yusrawati, Yusrawati   +8 more
core   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Lithium exposure during pregnancy: outcomes for women who attended a specialist antenatal clinic

Journal of Psychosomatic Obstetrics and Gynecology, 2018
Introduction: Lithium treatment in pregnancy represents a significant dilemma for women and treating health professionals alike. The complexity of risk-benefit analysis is impacted by limited information.
Jacqueline Frayne, Thinh Nguyen, Tabitha Mok, Yvonne Hauck, Helena Liira   +4 more
doaj   +1 more source