Results 41 to 50 of about 507,761 (297)

A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR

Scientific Reports, 2021
Animal studies have demonstrated the therapeutic potential of polyphenol-rich pomegranate juice. We recently reported altered white matter microstructure and functional connectivity in the infant brain following in utero pomegranate juice exposure in ...
Madeline M. Ross, Sara Cherkerzian, Nicole D. Mikulis, Daria Turner, Julian Robinson, Terrie E. Inder, Lillian G. Matthews   +6 more
doaj   +1 more source

Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin, Gregory Sahagian, Marc H. Feinberg, C. Andrew Stewart, Christopher M. Jewell, Metin Kurtoglu, Miloš D. Miljković, Tuan Vu, Tahseen Mozaffar, James F. Howard Jr, the MG‐001 Study Group   +10 more
wiley   +1 more source

Characteristics of Cerebral Palsy in the Midwestern US

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim, Kelsey Steffen, Lauren Gottschalk‐Henneberry, Jennifer Miros, Amy Robichaux‐Viehoever, Karen Taca, Bhooma R. Aravamuthan   +6 more
wiley   +1 more source

Patient reported outcome measures for use in pregnancy and childbirth: a systematic review

BMC Pregnancy and Childbirth, 2019
Background Globally, an increasing number of women give birth in a healthcare facility. Improvement in the quality of care is crucial if preventable maternal mortality and morbidity are to be reduced. A Patient Reported Outcome Measure (PROM) can be used
Fiona Dickinson, Mary McCauley, Helen Smith, Nynke van den Broek   +3 more
doaj   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source

Validation in Zambia of a cervical screening strategy including HPV genotyping and artificial intelligence (AI)-based automated visual evaluation

Infectious Agents and Cancer, 2023
Background WHO has recommended HPV testing for cervical screening where it is practical and affordable. If used, it is important to both clarify and implement the clinical management of positive results.
Groesbeck P. Parham, Didem Egemen, Brian Befano, Mulindi H. Mwanahamuntu, Ana Cecilia Rodriguez, Sameer Antani, Samson Chisele, Mukatimui Kalima Munalula, Friday Kaunga, Francis Musonda, Evans Malyangu, Aaron Lunda Shibemba, Silvia de Sanjose, Mark Schiffman, Vikrant V. Sahasrabuddhe   +14 more
doaj   +1 more source

Nanodiamond‐Infused Microgels for pH‐Tunable Rheology, Lubrication, and UV Protection

Advanced Functional Materials, EarlyView.
Microgels consisting of swollen polyacrylic acid polymer networks, impregnated with nanodiamonds provide protection from ultraviolet (UV) radiation harmful to human health. Nanodiamonds enable UV blockage and control of the rheology (flow) and lubrication (skin‐feel) of these microgel‐skincare‐mimics.
Pallav K. Jani, Sarvesh A. Nadkarni, Katherine J. Ernst, Barbara V. Farias, Chloe G. Hincher, Oluwatobi A. Ojuade, Yug C. Saraswat, Prottasha Sarker, Donald O. Freytes, Lilian C. Hsiao, Saad A. Khan   +10 more
wiley   +1 more source

Pathogenesis of rabies in a pregnant HIV immune-compromised woman in Zambia: A case report

Journal of Public Health in Africa
Rabies is a fatal neglected tropical zoonotic disease caused by neurotropic viruses of the genus Lyssavirus in the family Rhabdoviridae. We report the disease progression in a 30-year-old woman, in her eighth pregnancy, living with human immunodeficiency
Martin Nyahoda, Mukatimui K. Munalula, Agripa Lungu, Walter Muleya, Selia Ng’anjo, Willies Silwimba, Chrispin Mwando, Joyce N. Shampile   +7 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Sensing of Chloride Ions in Sweat by Means of Printed Extended‐Gate Organic Electrochemical Transistors

Advanced Functional Materials, EarlyView.
In this work, a platform based on an Extended‐Gate OECT is successfully developed and tailored for the detection of physiologically relevant chloride ion concentrations in artificial eccrine sweat. Leveraging the extended‐gate architecture, a high‐performance OECT based on inkjet‐printed pg2T‐TT is coupled with an inkjet‐printed Ag/AgCl electrode ...
Cristiano Bortolotti, Andrea Ottomaniello, Paola Parlanti, Virgilio Mattoli, Dario Natali, Andrea Aliverti, Adrica Kyndiah, Mario Caironi   +7 more
wiley   +1 more source