Results 101 to 110 of about 1,389,521 (207)

Comparison of diaphragmatic fatigue in newborn and older rabbits

open access: yes, 1988
The ability to maintain occlusion pressure (i.e., fatigability) during activation of the diaphragm via phrenic nerve stimulation was compared in newborn (less than 14 days old) and older (greater than 30 days old) rabbits.
H. A. Stogryn   +3 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

open access: yesAdvanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang   +10 more
wiley   +1 more source

ЭТИОЛОГИЯ ГАСТРОЭНТЕРИТОВ НОВОРОЖДЕННЫХ ТЕЛЯТ В РЕСПУБЛИКЕ ДАГЕСТАН

open access: yesВетеринарная патология, 2008
The facts about the role of viruses and bacteria in the aetiology of newborn calves diarrhea are presented in this article. In the unfortunate by gastrointestinal newborn calves diseases farms of Daghestan in the tests of material from sick animals and ...

doaj  

Treatment with novel Wnt antagonist XAV939 does not alter newborn dentate granule cell maturation in control animals.

open access: yes, 2019
(A) Images demonstrate eGFP+ newborn dentate granule cells two weeks after intrahippocampal saline injection (control) in the ipsilateral dorsal, ipsilateral ventral, and contralateral dentate gyrus, of mice treated with vehicle vs.
Kunal Gupta (7480829)   +1 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

open access: yesAdvanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang   +11 more
wiley   +1 more source

Acknowledgement to Reviewers of Animals in 2014

open access: yes, 2015
The editors of Animals would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...
Animals Office, Animals Editorial Office
core   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

open access: yesAdvanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally   +8 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

open access: yesAdvanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale   +23 more
wiley   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

open access: yesAdvanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu   +12 more
wiley   +1 more source

Spectrum of medium-chain acyl-CoA dehydrogenase deficiency detected by newborn screening

open access: yes, 2009
OBJECTIVE: Our goal was to describe the clinical spectrum of medium-chain acyl-CoA dehydrogenase deficiency detected by routine newborn screening and assess factors associated with elevations of octanoylcarnitine in newborns and characteristics ...
Grady, George F.   +7 more
core   +1 more source

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