Results 111 to 120 of about 110,880 (279)

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Verbal abuse during pregnancy increases frequency of newborn hearing screening referral: The Japan Environment and Children’s Study

, 2019
Kaori Komori, Masahiro Komori, Masamitsu Eitoku, Sifa Marie Joelle Muchanga, Hitoshi Ninomiya, Taisuke Kobayashi, Narufumi Suganuma   +6 more
openalex   +1 more source

Likely Impact of the COVID-19 Pandemic on Newborn Hearing Screening and Follow-up Services in the United States in 2020

, 2022
Kelly Dundon, Suhana Ema, Xidong Deng, Mia Morrison, Treeby W. Brown, Karl R. White, Linda Hazard, Marcia Fort, Kirsten Coverstone, Craig A. Mason, Marcus Gaffney   +10 more
openalex   +2 more sources

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

477 Newborn cystic fibrosis (CF) screening in Canada: considerations regarding the selection of a molecular genetic assay

, 2006
P.J. Bridgel, Denys Forrest, Jillian S. Parboosingh, Shalini Menon, Lisa Semple, Henry Wilde, C.L. Larsen, François P. Bernier, Max Lyon, Mark Montgomery   +9 more
openalex   +1 more source

Current State and Innovations in Newborn Screening: Continuing to Do Good and Avoid Harm [PDF]

, 2023
Giancarlo la Marca, Rachel S. Carling, Stuart J. Moat, Raquel Yahyaoui, Enzo Ranieri, James R. Bonham, Peter C. J. I. Schielen   +6 more
openalex   +1 more source

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

Newborn Screening

Newborn screening (NBS) programmes are considered to be one of the most successful secondary prevention measures in childhood to prevent or reduce morbidity and/or mortality via early disease identification and subsequent initiation of therapy. However, while many rare diseases can now be detected at an early stage using appropriate diagnostics, the ...
Hohenfellner, Katharina||, Elenberg, Ewa, Ariceta Iraola, Gema||, Nesterova, Galina, Soliman, Neveen A.||, Topaloglu, Rezan||   +5 more
openaire   +3 more sources

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

P619: Three years of newborn screening for MPS1 in Ontario: Challenges of screening for the severe end of a disease continuum

Genetics in Medicine Open
Melanie Lacaria, Matthew Henderson, Ed Yeh, Sara Fernandez, Kelsey Kalbfleisch, Kristin Kernohan, Pranesh Chakraborty   +6 more
doaj   +1 more source