Results 161 to 170 of about 3,396,540 (313)
ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief
Advanced Science, EarlyView.ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng +19 more
wiley +1 more source
A practical guide to Newborn Bloodspot Screening in Ireland [PDF]
, 2011 The newborn screening programme for phenylketonuria was started in Ireland the Children’s University Hospital, Temple Street in February 1966. The Irish programme was one of the first national programmes in the world. All babies born on or after 1st July
National Newborn Bloodspot Screening Laboratory Children’s University Hospital Temple Street, Dublin +1 more
core
Advanced Science, EarlyView.We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar +4 more
wiley +1 more source
Newborn Screening Healthcare Information System Based on Service-Oriented Architecture
, 2011 In this paper, we established a newborn screening system under the HL7/ Web Services frameworks. We rebuilt the NTUH Newborn Screening Laboratory 's original standalone architecture, having various heterogeneous systems operating individually, and ...
謝嵩淮;謝筱齡;簡穎秀;翁永卿;許凱平;陳啟煌;杜建明;賴飛羆 +1 more
core +1 more source
International Journal of Neonatal ScreeningThis study aims to investigate the genotype characteristics of newborns with biallelic GJB2 mutations and their correlation with hearing phenotypes, providing a basis for clinical genetic counseling and hearing management.
Jianjun Li, Bo Wu, Wenlan Liu
doaj +1 more source
Advanced Science, EarlyView.A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo +18 more
wiley +1 more source
, 2015 PURPOSE: The US Secretary of Health and Human Services provides guidance to state newborn screening programs about which conditions should be included in screening (i.e., the "Recommended Uniform Screening Panel").
Tanksley, Susan +9 more
core +1 more source
Advanced Science, EarlyView.In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang +19 more
wiley +1 more source
Incidence of severe combined immunodeficiency through newborn screening in a Chinese population
, 2017 Background/Purpose: In order to know the true incidence of severe combined immunodeficiency (SCID) in a Chinese population, we conducted and implemented SCID newborn screening in Taiwan.
Chien, Yin-Hsiu;Chian, Shu-Chuan;Chang, Kai-Ling;Yu, Hsin-Hui;Lee, Wen-I;Tsai, Li-Ping;Hsu, Li-Wen;Hu, Min-Huei;Hwu, Wuh-Liang +1 more
core +1 more source
Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment
Advanced Science, EarlyView.This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo +15 more
wiley +1 more source