Results 181 to 190 of about 282,476 (297)

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie   +18 more
wiley   +1 more source

MicroRNA-320а as a novel biomarker at preclinical stage of necrotizing enterocolitis in term neonates with congenital heart defects. [PDF]

open access: yesWorld J Clin Pediatr
Zaikova EK   +6 more
europepmc   +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

open access: yesAdvanced Science, EarlyView.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li   +13 more
wiley   +1 more source

Pathogenic Staphylococci in the Environment of the Newborn Infant [PDF]

open access: green, 1955
P. N. Edmunds   +3 more
openalex   +1 more source

Mechanical Force Storage and Reprogramming Hydrogel for Scarless Repair of Sports Joint Wounds

open access: yesAdvanced Science, EarlyView.
Inspired by the energy conversion of tendons, the “energy transit station” hydrogel is designed. The hydrogel not only shields stress concentration in sports injuries, but also reprograms energy forms to provide reasonable biomimetic contraction for wounds.
Jiakang Zhang   +10 more
wiley   +1 more source

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