Results 181 to 190 of about 799,457 (416)

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

open access: yesAdvanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei   +15 more
wiley   +1 more source

Microbiological study of neonatal conjunctivitis with special reference to chlamydia trachomatis.

open access: yesIndian Journal of Ophthalmology, 2002
PURPOSE: To study the microbial agents, chiefly Chlamydia trachomatis and other bacteria, in neonatal conjunctivitis. METHODS: Conjunctival specimens from 70 newborns with conjunctivitis were subjected to bacterial culture and sensitivity testing ...
Mohile Mukula   +4 more
doaj  

Congenital malformations at a referral hospital in Gorgan, Islamic Republic of Iran [PDF]

open access: yes, 2005
This study recorded the rate of congenital malformations in 10 000 births at a referral hospital in Gorgan, Islamic Republic of Iran in 1998-99. The overall incidence of congenital malformations was 1.01% (1.19% in males and 0.76% in females).
Ahmadpour-Kacho, M.   +2 more
core  

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

open access: yesAdvanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng   +11 more
wiley   +1 more source

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2010
M. Dominguez-Bello   +6 more
semanticscholar   +1 more source

The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

open access: yesAdvanced Science, EarlyView.
RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp   +5 more
wiley   +1 more source

Implications of holdfast availability and patchiness on juvenile seahorse (Hippocampus reidi) condition and welfare: Simulations in captivity

open access: yesAquaculture, Fish and Fisheries, Volume 2, Issue 6, Page 552-561, December 2022., 2022
Abstract Seahorses (Genus Hippocampus; Family Syngnathidae) are iconic fish characterised by tails with prehensile capabilities, which develop after the transition from planktonic to benthonic lifestyle. As a result, seahorses remain attached to vegetal structures or other elements most of the time, both in the wild and under rearing conditions. In the
Miquel Planas
wiley   +1 more source

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