Results 41 to 50 of about 255,153 (264)

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Survival at What Cost? Origins and Effects of the Modern Controversy on Treating Severely Handicapped Newborns

open access: yes, 1986
Reiser traces the origins of current controversies in the care of handicapped newborns to the development of life-prolonging technologies, increased participation by patients and their families in decision making, greater federal involvement in ...
Reiser, Stanley J.
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Global Maternal and Newborn Health Platform: study protocol for an observational, multi-country study on the quality of intrapartum and early postnatal care at health facilities

open access: yesBMC Public Health
Background Good-quality care in the intrapartum and early postnatal period are critical to ensuring maternal, fetal and newborn survival and well-being. There is currently no standardised approach to assess the quality of intrapartum and early postnatal ...
The Global Maternal and Newborn Health Platform – Asia-Pacific Research Group
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Clinical case of late neonatal hemorrhagic disease. Hazards for the family doctor. Modern recommendations for prevention

open access: yesZdorovʹe Rebenka, 2020
The article presents a clinical course and components of the treatment of a hemorrhagic syndrome caused by late vitamin K deficiency in a full-term girl of 28 days of age.
M.M. Kiselova, G.V. Koshulap
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

A Meta-Analysis of Mean Vitamin D Concentration among Pregnant Women and Newborns in Iran [PDF]

open access: yesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2017
Introduction: Pregnant women and newborns are at risk of vitamin D deficiency (VDD). VDD during pregnancy can lead to several maternal and fetal complications.
Milad Azami   +9 more
doaj   +1 more source

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