Results 201 to 210 of about 298,387 (354)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Is there still room for pioglitazone in contemporary type 2 diabetes management? [PDF]

Cardiovasc Diabetol
Caruso I.
europepmc   +1 more source

Packaging Fatwa in the Post Truth Era: MUI Fatwa Contest Facing New Religious Authority

Achmad Muhibin Zuhri, Winarto Eka Wahyudi, Ilham Dwitama Haeba   +2 more
openalex   +2 more sources

23 / EMBELLISHING THE TOKUHASHI SCORE IN THE ERA OF NEWER SYSTEMIC THERAPIES [PDF]

, 2018
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Optimizing Crohn's Disease Management in the Biologic Era-Insights from Real-World Evidence in Japan. [PDF]

JMA J
Fukuzawa M.
europepmc   +1 more source

Social interventions: a new era for global mental health?

, 2019
Rochelle A. Burgess, Sumeet Jain, Inge Petersen, Crick Lund   +3 more
openalex   +2 more sources

Hepatitis C in Pregnancy - Universal Screening in the Era of Newer Antivirals

Journal of Gynecology and Womens Health, 2017
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

What are the Real Achievements in Spine Surgery? [PDF]

Global Spine J
Chapman JR, Wang JC, Wiechert K.
europepmc   +1 more source