Results 251 to 260 of about 19,456,354 (363)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Rethinking Maternal Obesity Research in a Changing Clinical Landscape. [PDF]

Paediatr Perinat Epidemiol
Hutcheon JA, Bodnar LM.
europepmc   +1 more source

Effective Practices of Enhancing Students' Safety Awareness in Teaching Laboratories in the New Era [PDF]

Xu Hu
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Follow-up of neonatal chronic respiratory disease: an update based on the current evidence. [PDF]

Eur J Pediatr
Jenkinson A, Dassios T.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Bariatric Surgery in the Era of GLP1RA: A Narrative Review. [PDF]

Adv Ther
Muhundan M, Dash S.
europepmc   +1 more source

Research on the Way to Carry Out Ideological and Political Education for the “Post-2000s” of Colleges in the New Media Era

, 2020
Meihui Wang, Qizhi Ning
openalex   +1 more source

TCT-460 Clinical Impact of Complete Coronary Revascularization by Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion in the First and Newer Drug-Eluting Stent Generation Era

Journal of the American College of Cardiology, 2017
Renato Valenti, Angela Migliorini, Andrea Bernardini, Maria Grazia De gregorio, Raffaele Martone, Maria Raffaella Aicale, Sofia Morini, Ruben Vergara, Martina Berteotti, Nazario Carrabba, David Antoniucci   +10 more
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source