Results 191 to 200 of about 5,219 (246)

External beam radiation for HCC: Ready for incorporation into guidelines? [PDF]

JHEP Rep
Buckstein M, Dawson LA.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A Paradigm Shift in Progress: Generative AI's Evolving Role in Mental Health Care.

JMIR Ment Health
Torous J, Cipriani A.
europepmc   +1 more source

Can we trust academic AI detective? Accuracy and limitations of AI-output detectors. [PDF]

Acta Neurochir (Wien)
Erol G, Ergen A, Gülşen Erol B, Kaya Ergen Ş, Bora TS, Çölgeçen AD, Araz B, Şahin C, Bostancı G, Kılıç İ, Macit ZB, Sevgi UT, Güngör A.   +12 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

HIV-1 Drug Resistance Trends in the Era of Modern Antiretrovirals: 2018-2024. [PDF]

Open Forum Infect Dis
Kagan RM, Baxter JD, Kim T, Marlowe EM.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A First Evaluation of ERA-20CM over China

, 2016
Lu Gao, M. Bernhardt, K. Schulz, Xing-wei Chen, Ying Chen, Mei-bing Liu   +5 more
semanticscholar   +1 more source

Prenatal Management of Spinal Muscular Atrophy in the Era of Genetic Screening and Emerging Opportunities in In Utero Therapy. [PDF]

Biomedicines
Mežnarić S, Belančić A, Rački V, Vitezić D, Mršić-Pelčić J, Pilipović K.   +5 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source