Results 221 to 230 of about 157,079 (340)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Effect of bedside comprehensive ability training on teaching and training in operating room. [PDF]

Front Med (Lausanne)
Zhong Y, Bu W, Li Q, Zheng L.
europepmc   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Programmable Semi‐Interpenetrating Living Materials With Robust Stability for Versatile Bioremediation and Biotherapeutics

Advanced Science, EarlyView.
A semi‐interpenetrating engineered living material (sIHSELM), fabricated via thermosensitive hydroxybutyl chitosan and covalent protein self‐assembly, demonstrates exceptional mechanical properties and environmental stability. Shielding bacteria from harsh conditions, sIHSELM exhibits remarkable efficacy in ulcerative colitis treatment and pollutants ...
Zixian Bao, Shengfeng Yang, Dandan Hu, Jiezheng Liu, Bo Jiang, Xinyue Sui, Qingsheng Qi, Lai Li, Guang Zhao   +8 more
wiley   +1 more source

Moral Courage and Ethical Decision-Making Among Registered Psychiatric Nurses in Western Canada: A Cross-Sectional Multiple-Methods Study. [PDF]

Int J Ment Health Nurs
McBride J, Chachula K.
europepmc   +1 more source

A longitudinal study on the prevention and intervention of burnout in newly recruited nurses: Part 1

The Proceedings of the Annual Convention of the Japanese Psychological Association, 2010
Tokumi UENO, Yoshifumi YAMAMOTO, Shinya MASUDA, Kazuyo KITAOKA-HIGASHIGUCHI   +3 more
openaire   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Constructing a Multidimensional Entrepreneurial Leadership Competency Model Amongst Nurse Leaders of New Hospitals in China: A Mixed-Methods Study. [PDF]

J Nurs Manag
Gong J, Yang B, Sun L, Deng X, Zhao Y, He F, Zhou J.   +6 more
europepmc   +1 more source

A longitudinal study on the prevention and intervention of burnout in newly recruited nurses: Part 2

The Proceedings of the Annual Convention of the Japanese Psychological Association, 2010
Yoshifumi YAMAMOTO, Tokumi UENO, Shinya MASUDA, Kazuyo KITAOKA-HIGASHIGUCHI   +3 more
openaire   +2 more sources

THE EFFECTIVENESS OF THE ORIENTATION PROGRAMME ON NEWLY RECRUITED BASIC BSC STAFF NURSES AT KRISHNA HOSPITAL, KARAD

Journal of Evolution of Medical and Dental Sciences, 2016
Rohini Babar, Kavita Kapurkar S, Sandhya Jagadale, Jadhav K S, Jagtap M P, Talbar S J   +5 more
openaire   +1 more source