Results 191 to 200 of about 348,334 (245)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Determining a Clinically Applicable Cutoff in AI Algorithms for Predicting Clinical Deterioration: A Workload-Constrained, Alarm-Based Approach. [PDF]

J Clin Med
Jang J, Choi YJ, Sim T, Lee KB, Kim JH, Cho EY, Choi Y, Hong S, Jung BM, Kim SJ, Hong WG, Cho JH.   +11 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Accuracy of prognostic scoring tools for ICU triage and mortality among patients in low- and middle-income countries: a systematic review and meta-analysis. [PDF]

BMJ Open Respir Res
Tran TH, Nguyen HTT, Tran TH.
europepmc   +1 more source

Strategies for tackling fake news in healthcare: a complex approach from a nursing perspective. [PDF]

Rev Esc Enferm USP
Costa LDS, Ventura CAA, Marcon SS, Duarte SDCM, Silva TPD, Nogueira ALA, Silva ÍR.   +6 more
europepmc   +1 more source

Mapping Human-AI Teaming in Risk Analysis: Role Evolution, Thematic Landscape, and Governance Mechanisms From News Media. [PDF]

Risk Anal
Cheng C, Dai J, Yan L.
europepmc   +1 more source

Mabast dataset for Sorani Kurdish dialect semantic text classification. [PDF]

Data Brief
Hasan IE, Al-Atroshi SJA.
europepmc   +1 more source

Translating JAH Science: Infographics for Enhanced Dissemination and Engagement in Adolescent Health Research. [PDF]

J Adolesc Health
Hur JO, Helmer CK, Iglesias K, Li C, Alsamman H, Nagata JM.   +5 more
europepmc   +1 more source

Correction to: Nudging recommendation algorithms increases news consumption and diversity on YouTube. [PDF]

PNAS Nexus
europepmc   +1 more source