Results 71 to 80 of about 348,334 (245)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
EnergiesThe growing population and increasingly competitive economic climate have increased the demand for alternative fuel sources, with hydrogen being one of the more viable options.
Erik Biehler +2 more
doaj +1 more source
BMJ, 1999 Long ago I used to read Time magazine every week; I liked to be kept informed about what was happening round the world, in an objective and concise fashion. Then I began to realise how inaccurate its coverage of the Northern Ireland troubles was, and my doubts began to grow.
openaire +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Instanton effects in twist-3 generalized parton distributions
Physics Letters BThe instanton vacuum picture is used to study hadronic matrix elements of the twist-3 (dimension-4, spin-1) QCD operators measuring the quark spin density and spin-orbit correlations.
June-Young Kim, Christian Weiss
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Frontiers in Public HealthBackgroundChinese college students often use social media to access sexual health information in a context of uneven formal sex education and cultural sensitivity surrounding sexuality.
Zhuowen Feng +4 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
“I Don’t Understand It”: Australians’ Low Interest in Politics and Political News
International Journal of CommunicationResearch shows that while a significant portion of Australians are not interested in politics or political news, those who are interested in politics tend to consume a lot of news in general.
Caroline Fisher +4 more
doaj