Results 51 to 60 of about 14,397 (261)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

The role of emotional styles in information avoidance regarding negative news

open access: yesInformation Research: An International Electronic Journal
Introduction. This study explores the influence of emotional styles on students’ information avoidance behaviour, particularly about negative news. Method. Using a sample of participants, we employed the Emotional Styles Questionnaire (ESQ) to measure
Mahsa Torabi   +2 more
doaj   +1 more source

Sjeldenkonsumenter av nyheter: Holdning til nyhetsmedier, medborgerskap og forklaringer på sjeldenkonsum blant unge voksne

open access: yesNorsk Medietidsskrift, 2017
Sammendrag Sjeldenkonsumenter av nyheter anses ofte i forskningsdiskursen som et demokratisk problem. Imidlertid har forskningen liten innsikt i deres livsverden.
Anders Helgerud
doaj   +1 more source

Risk perception and avoidance of preventive behavior on the COVID‐19 among cancer patients

open access: yesHealth Science Reports, 2023
Background and Aims Willingness to engage in preventive behaviors against coronavirus disease 2019 (COVID‐19) depends on people's risk perception.
Mehdi Khezeli   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

INFORMATION AVOIDANCE BEHAVIOR REGARDING HOAXES INDICATORS

open access: yesJurnal Psikologi Undip, 2020
Hoaxes have become a common phenomenon in Indonesia. The Indonesian Telematics Society Survey shows that even though Indonesian people understand the way in recognizing hoaxes, they Indonesia are not sure of being able to immediately recognize hoaxes ...
Raymond Godwin   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

What Leads to Audience Issue Fatigue? A Linkage Analysis Study on the Effects of News Coverage on Fatigue From Ongoing News Issues

open access: yesInternational Journal of Communication, 2023
The news media cover certain political issues extensively for weeks, months, or years, leading the audience to become fatigued. Audience fatigue from and avoidance of ongoing political news issues are detrimental to an informed citizenry and problematic ...
Gwendolin Gurr, Julia Metag
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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